Infection, Immunity and Inflammation
Infection, Immunity and Inflammation – III
Research related to infection and subsequent host response; innate and adaptive immunity; inflammatory responses; genetic evaluation of virulence that affect colonization of tissues and systems; disease pathologies related to inflammation and immune dysfunction; e.g., diabetes, neurodegenerative disease; mesenchymal stem cells differentiation for immune function and wound healing.
Faculty
Helene Andrews-Polymenis, DVM, PhD
handrews@tamu.edu | 979.436.0340 | Office: MREB, 3008
Research Interest
Salmonella Infection
Graduate Program Affiliation
Publications
- Elfenbein JR, Knodler LA, Nakayasu ES, et al. Multicopy Single-Stranded DNA Directs Intestinal Colonization of Enteric Pathogens. PLoS Genet. 2015;11(9):e1005472. Published 2015 Sep 14. doi:10.1371/journal.pgen.1005472
- Bogomolnaya LM, Andrews KD, Talamantes M, et al. The ABC-type efflux pump MacAB protects Salmonella enterica serovar typhimurium from oxidative stress. mBio. 2013;4(6):e00630-13. Published 2013 Oct 29. doi:10.1128/mBio.00630-13
- Bogomolnaya LM, Tilvawala R, Elfenbein JR, Cirillo JD, Andrews-Polymenis HL. Linearized Siderophore Products Secreted via MacAB Efflux Pump Protect Salmonella enterica Serovar Typhimurium from Oxidative Stress. mBio. 2020;11(3):e00528-20. Published 2020 May 5. doi:10.1128/mBio.00528-20
Carolyn Cannon, MD, PhD
carolyn.cannon@tamu.edu | 832.822.3300 | Office: MREB-II, 3342
Research Interest
Novel antimicrobials, MDR bacterial infections, cystic fibrosis, host-pathogen interactions
Graduate Program Affiliation
Publications
- Kang D, Revtovich AV, Chen Q, Shah KN, Cannon CL, Kirienko NV. Pyoverdine-Dependent Virulence of Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients. Front Microbiol. 2019;10:2048. Published 2019 Sep 6. doi:10.3389/fmicb.2019.02048
- Shah PN, Marshall-Batty KR, Smolen JA, et al. Antimicrobial Activity of Ibuprofen against Cystic Fibrosis-Associated Gram-Negative Pathogens. Antimicrob Agents Chemother. 2018;62(3):e01574-17. Published 2018 Feb 23. doi:10.1128/AAC.01574-17
- Shah PN, Shah KN, Smolen JA, et al. A novel in vitro metric predicts in vivo efficacy of inhaled silver-based antimicrobials in a murine Pseudomonas aeruginosa pneumonia model. Sci Rep. 2018;8(1):6376. Published 2018 Apr 23. doi:10.1038/s41598-018-24200-w
Adam Case, PhD
acase@tamu.edu | 979.436.9709 | Office: MREB-II, 3414
Research Interest
Redox signaling in the immune system
Graduate Program Affiliation
Publications
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Moshfegh CM, Collins CW, Gunda V, Vasanthakumar A, Cao JZ, Singh PK, Godley LA, Case AJ. Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes. Redox Biol. 2019 Oct;27:101141. doi: 10.1016/j.redox.2019.101141. Epub 2019 Feb 21. PMID: 30819616; PMCID: PMC6859572.
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Case AJ, Roessner CT, Tian J, Zimmerman MC. Mitochondrial Superoxide Signaling Contributes to Norepinephrine-Mediated T-Lymphocyte Cytokine Profiles. PLoS One. 2016 Oct 11;11(10):e0164609. doi: 10.1371/journal.pone.0164609. PMID: 27727316; PMCID: PMC5058488.
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Case AJ, McGill JL, Tygrett LT, Shirasawa T, Spitz DR, Waldschmidt TJ, Legge KL, Domann FE. Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radic Biol Med. 2011 Feb 1;50(3):448-58. doi: 10.1016/j.freeradbiomed.2010.11.025. Epub 2010 Dec 2. PMID: 21130157; PMCID: PMC3026081.
Sanjukta Chakraborty, PhD
schakraborty@tamu.edu | 979.436.0697 | Office: MREB-II, 2416
Research Interest
Lymphatic inflammation, chemokine interactions, immune suppression, signaling pathways
Graduate Program Affiliation
Publications
- Chakraborty S, Zawieja DC, Davis MJ, Muthuchamy M. MicroRNA signature of inflamed lymphatic endothelium and role of miR-9 in lymphangiogenesis and inflammation [published correction appears in Am J Physiol Cell Physiol. 2020 May 1;318(5):C1042-C1043]. Am J Physiol Cell Physiol. 2015;309(10):C680-C692. doi:10.1152/ajpcell.00122.2015
- Chakraborty S, Nepiyushchikh Z, Davis MJ, Zawieja DC, Muthuchamy M. Substance P activates both contractile and inflammatory pathways in lymphatics through the neurokinin receptors NK1R and NK3R. Microcirculation. 2011;18(1):24-35. doi:10.1111/j.1549-8719.2010.00064.x
- Lee Y, Fluckey JD, Chakraborty S, Muthuchamy M. Hyperglycemia- and hyperinsulinemia-induced insulin resistance causes alterations in cellular bioenergetics and activation of inflammatory signaling in lymphatic muscle. FASEB J. 2017;31(7):2744-2759. doi:10.1096/fj.201600887R
Jeffrey Cirillo, PhD
jdcirillo@tamu.edu | 979.436.0343 | Office: MREB-II, 3350
Research Interest
Molecular pathogenesis, therapeutics, vaccines and diagnostics
Graduate Program Affiliation
Publications
- Galbadage T, Liu D, Alemany LB, et al. Molecular Nanomachines Disrupt Bacterial Cell Wall, Increasing Sensitivity of Extensively Drug-Resistant Klebsiella pneumoniae to Meropenem. ACS Nano. 2019;13(12):14377-14387. doi:10.1021/acsnano.9b07836
- Sule P, Tilvawala R, Mustapha T, et al. Rapid Tuberculosis Diagnosis Using Reporter Enzyme Fluorescence. J Clin Microbiol. 2019;57(12):e01462-19. Published 2019 Nov 22. doi:10.1128/JCM.01462-19
- Christensen LM, Sule P, Cirillo SLG, et al. Legionnaires' Disease Mortality in Guinea Pigs Involves the p45 Mobile Genomic Element. J Infect Dis. 2019;220(10):1700-1710. doi:10.1093/infdis/jiz340
Shannon Glaser, PhD
sglaser@tamu.edu | 979.436.9260 | Office: MREB-II, 2342
Research Interest
Inflammation during chronic liver diseases, cholestasis, alcohol induced liver damage
Graduate Program Affiliation
Publications
- Kyritsi K, Chen L, O'Brien A, et al. Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis. Hepatology. 2020;71(3):990-1008. doi:10.1002/hep.30880
- Chen L, Zhou T, Wu N, et al. Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis. Biochim Biophys Acta Mol Basis Dis. 2019;1865(6):1525-1539. doi:10.1016/j.bbadis.2019.03.002
- Zhou T, Kyritsi K, Wu N, et al. Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2-/- mouse model of primary sclerosing cholangitis (PSC). EBioMedicine. 2019;48:130-142. doi:10.1016/j.ebiom.2019.09.013
Michelle Hook, PhD
michellehook@tamu.edu | 979.436.0568
Research Interest
Recovery of function following a spinal cord injury (SCI)
Graduate Program Affiliation
Publications
- Aceves M, Terminel MN, Okoreeh A, et al. Morphine increases macrophages at the lesion site following spinal cord injury: Protective effects of minocycline. Brain Behav Immun. 2019;79:125-138. doi:10.1016/j.bbi.2019.01.023
- Maldonado-Bouchard S, Peters K, Woller SA, et al. Inflammation is increased with anxiety- and depression-like signs in a rat model of spinal cord injury. Brain Behav Immun. 2016;51:176-195. doi:10.1016/j.bbi.2015.08.009
- Metzger CE, Gong S, Aceves M, Bloomfield SA, Hook MA. Osteocytes reflect a pro-inflammatory state following spinal cord injury in a rodent model. 2019;120:465-475. doi:10.1016/j.bone.2018.12.007
David Huston, MD
dhuston@tamu.edu| 713.677.8110 | Office: ALKEK 1111
Research Interest
The biology of allergic inflammation with emphasis on the structure/ function of IL3, IL5, and GMCSF
Graduate Program Affiliation
Publications
- Huston DP. Unneutral neutrophils in patients with late-phase allergic reactions. J Allergy Clin Immunol. 2019;144(1):46-48. doi:10.1016/j.jaci.2019.03.023
- Huston DP, Sabato V. Decoding the Enigma of Urticaria and Angioedema [published correction appears in J Allergy Clin Immunol Pract. 2018 Sep - Oct;6(5):1810-1812]. J Allergy Clin Immunol Pract. 2018;6(4):1171-1175. doi:10.1016/j.jaip.2018.06.001
- Cromheecke JL, Nguyen KT, Huston DP. Emerging role of human basophil biology in health and disease. Curr Allergy Asthma Rep. 2014;14(1):408. doi:10.1007/s11882-013-0408-2
Jenny Hyde, PhD
jhyde@tamu.edu | 979.436.0872 | Office: MREB, 3002
Research Interest
Pathogenic mechanisms of Borrelia burgdorferi for infection and inflammation
Graduate Program Affiliation
Publications
- Skare JT, Shaw DK, Trzeciakowski JP, Hyde JA. In Vivo Imaging Demonstrates That Borrelia burgdorferi ospC Is Uniquely Expressed Temporally and Spatially throughout Experimental Infection. PLoS One. 2016;11(9):e0162501. Published 2016 Sep 9. doi:10.1371/journal.pone.0162501
- Gilmore RD, Brandt KS, Hyde JA. pncA and bptA are not sufficient to complement Ixodes scapularis colonization and persistence by Borrelia burgdorferi in a linear plasmid lp25-deficient background. Infect Immun. 2014;82(12):5110-5116. doi:10.1128/IAI.02613-14
- Medina-Pérez DN, Wager B, Troy E, et al. The intergenic small non-coding RNA ittA is required for optimal infectivity and tissue tropism in Borrelia burgdorferi. PLoS Pathog. 2020;16(5):e1008423. Published 2020 May 4. doi:10.1371/journal.ppat.1008423
Jason Karpac, PhD
karpac@tamu.edu | 979.436.0767 | Office: MREB-II, 4342
Research Interest
Exploring innate immune-metabolic signaling network integration using Drosophila
Graduate Program Affiliation
- Medical Science PhD Program
- Interdisciplinary Graduate Program in Genetics
- Biomedical Sciences Graduate Program
Publications
- Molaei M, Vandehoef C, Karpac J. NF-κB Shapes Metabolic Adaptation by Attenuating Foxo-Mediated Lipolysis in Drosophila. Dev Cell. 2019;49(5):802-810.e6. doi:10.1016/j.devcel.2019.04.009
- Vandehoef C, Molaei M, Karpac J. Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP. Cell Rep. 2020;31(10):107736. doi:10.1016/j.celrep.2020.107736
- Mlih M, Khericha M, Birdwell C, West AP, Karpac J. A virus-acquired host cytokine controls systemic aging by antagonizing apoptosis. PLoS Biol. 2018;16(7):e2005796. Published 2018 Jul 23. doi:10.1371/journal.pbio.2005796
Julian Leibowitz, MD, PhD
jleibowitz@tamu.edu | 979.436.0313 | Office: MREB-II, 3224C
Research Interest
Coronavirus pathogenesis
Graduate Program Affiliation
- Medical Science PhD Program
- Interdisciplinary Graduate Program in Genetics
- Texas A&M University Institute for Neuroscience
Publications
- De Albuquerque N, Baig E, Ma X, et al. Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice. J Virol. 2006;80(21):10382-10394. doi:10.1128/JVI.00747-06
- Wippold JA, Wang H, Tingling J, Leibowitz JL, de Figueiredo P, Han A. PRESCIENT: platform for the rapid evaluation of antibody success using integrated microfluidics enabled technology. Lab Chip. 2020;20(9):1628-1638. doi:10.1039/c9lc01165j
- Yang D, Liu P, Wudeck EV, Giedroc DP, Leibowitz JL. SHAPE analysis of the RNA secondary structure of the Mouse Hepatitis Virus 5' untranslated region and N-terminal nsp1 coding sequences. Virology. 2015;475:15-27. doi:10.1016/j.virol.2014.11.001
Fei Liu, PhD
fliu@tamu.edu | 979.436.9642 | Office: REYNOLDS, 242B
Research Interest
Treatment of autoimmune diseases with mesenchymal stem cell extracellular vesicles
Graduate Program Affiliation
Publications
- Hai B, Shigemoto-Kuroda T, Zhao Q, Lee RH, Liu F. Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of Sjögren's Syndrome. Stem Cells Int. 2018;2018:2092315. Published 2018 Mar 15. doi:10.1155/2018/2092315
Alistair McGregor, PhD
mcgalistair2013@tamu.edu| 979.436.9400 | Office: MREB-II, 3348
Research Interest
Innate & adaptive immunity to cytomegalovirus (CMV). Virus virulence factors and interventions for cmv
Graduate Program Affiliation
Publications
- Choi KY, El-Hamdi NS, McGregor A. Neutralizing antibodies to gB based CMV vaccine requires full length antigen but reduced virus neutralization on non-fibroblast cells limits vaccine efficacy in the guinea pig model. 2020;38(10):2340-2349. doi:10.1016/j.vaccine.2020.01.063
- Choi KY, El-Hamdi NS, McGregor A. Inclusion of the Viral Pentamer Complex in a Vaccine Design Greatly Improves Protection against Congenital Cytomegalovirus in the Guinea Pig Model. J Virol. 2019;93(22):e01442-19. Published 2019 Oct 29. doi:10.1128/JVI.01442-19
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Coleman S, Choi KY, Root M, McGregor A. A Homolog Pentameric Complex Dictates Viral Epithelial Tropism, Pathogenicity and Congenital Infection Rate in Guinea Pig Cytomegalovirus. PLoS Pathog. 2016;12(7):e1005755. Published 2016 Jul 7. doi:10.1371/journal.ppat.1005755
Brett Mitchell, PhD
brettmitchell@tamu.edu | 979.436.0751 | Office: MREB-II, 2412
Research Interest
Immunity and inflammation in hypertension
Graduate Program Affiliation
Publications
- Balasubbramanian D, Lopez Gelston CA, Rutkowski JM, Mitchell BM. Immune cell trafficking, lymphatics and hypertension. Br J Pharmacol. 2019;176(12):1978-1988. doi:10.1111/bph.14370
- Chiasson VL, Bounds KR, Chatterjee P, et al. Myeloid-Derived Suppressor Cells Ameliorate Cyclosporine A-Induced Hypertension in Mice. Hypertension. 2018;71(1):199-207. doi:10.1161/HYPERTENSIONAHA.117.10306
- Chatterjee P, Chiasson VL, Seerangan G, et al. Depletion of MHC class II invariant chain peptide or γ-δ T-cells ameliorates experimental preeclampsia. Clin Sci (Lond). 2017;131(15):2047-2058. Published 2017 Jul 16. doi:10.1042/CS20171008
Mariappan Muthuchamy, PhD
marim@tamu.edu | 979.436.9264 | Office: MREB-II, 2410
Research Interest
Regulatory roles of lymphatics in inflammation
Graduate Program Affiliation
Publications
- Chakraborty S, Zawieja S, Wang W, Zawieja DC, Muthuchamy M. Lymphatic system: a vital link between metabolic syndrome and inflammation. Ann N Y Acad Sci. 2010;1207 Suppl 1(Suppl 1):E94-E102. doi:10.1111/j.1749-6632.2010.05752.x
- Zawieja SD, Wang W, Chakraborty S, Zawieja DC, Muthuchamy M. Macrophage alterations within the mesenteric lymphatic tissue are associated with impairment of lymphatic pump in metabolic syndrome. Microcirculation. 2016;23(7):558-570. doi:10.1111/micc.12307
- Chakraborty S, Gurusamy M, Zawieja DC, Muthuchamy M. Lymphatic filariasis: perspectives on lymphatic remodeling and contractile dysfunction in filarial disease pathogenesis. Microcirculation. 2013;20(5):349-364. doi:10.1111/micc.12031
Kristin Patrick, PhD
kpatrick03@tamu.edu | 979.436.0354 | Office: MREB, 3102
Research Interest
Post-transcriptional control of innate immune gene expression
Graduate Program Affiliation
Publications
- West KO, Scott HM, Torres-Odio S, West AP, Patrick KL, Watson RO. The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages. Cell Rep. 2019;29(6):1594-1609.e5. doi:10.1016/j.celrep.2019.09.078
- Weindel CG, Bell SL, Vail KJ, West KO, Patrick KL, Watson RO. LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis. Elife. 2020;9:e51071. Published 2020 Feb 14. doi:10.7554/eLife.51071
- Hoffpauir CT, Bell SL, West KO, et al. TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection. J Immunol. 2020;205(1):153-167. doi:10.4049/jimmunol.1901511
Joseph Rutkowski, PhD
rutkowski@tamu.edu | 979.436.0576 | Office: MREB-II, 2414
Research Interest
How chronic inflammatory disease and tissue injury are impacted by lymphatic-immune cell modulation.
Graduate Program Affiliation
Publications
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Chakraborty A, Scogin CK, Rizwan K, Morley TS, Rutkowski JM. Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D. Front Physiol. 2020;11:363. Published 2020 Apr 22. doi:10.3389/fphys.2020.00363
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Abouelkheir GR, Upchurch BD, Rutkowski JM. Lymphangiogenesis: fuel, smoke, or extinguisher of inflammation's fire?. Exp Biol Med (Maywood). 2017;242(8):884-895. doi:10.1177/1535370217697385
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Wernstedt Asterholm I, Kim-Muller JY, Rutkowski JM, Crewe C, Tao C, Scherer PE. Pathological Type-2 Immune Response, Enhanced Tumor Growth, and Glucose Intolerance in Retnlβ (RELMβ) Null Mice: A Model of Intestinal Immune System Dysfunction in Disease Susceptibility. Am J Pathol. 2016;186(9):2404-2416. doi:10.1016/j.ajpath.2016.04.017
Lee Shapiro, PhD
lshapiro@tamu.edu | 979.436.0272 | Office: MREB
Research Interest
Immune/Neuroimmune axis in brain disorders
Graduate Program Affiliation
Publications
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Tobin RP, Mukherjee S, Kain JM, et al. Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration. Acta Neuropathol Commun. 2014;2:143. Published 2014 Oct 20. doi:10.1186/s40478-014-0143-5
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Nizamutdinov D, Shapiro LA. Overview of Traumatic Brain Injury: An Immunological Context. Brain Sci. 2017;7(1):11. Published 2017 Jan 23. doi:10.3390/brainsci7010011
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Mukherjee S, Arisi GM, Mims K, Hollingsworth G, O'Neil K, Shapiro LA. Neuroinflammatory mechanisms of post-traumatic epilepsy. J Neuroinflammation. 2020;17(1):193. Published 2020 Jun 17. doi:10.1186/s12974-020-01854-w
Jon Skare, PhD
jskare@tamu.edu | 979.436.0353 | Office: MREB, 3004
Research Interest
Bacterial pathogenesis, Lyme disease, Arthropod disease transmission, vector-borne diseases
Graduate Program Affiliation
Publications
- Medina-Pérez DN, Wager B, Troy E, et al. The intergenic small non-coding RNA ittA is required for optimal infectivity and tissue tropism in Borrelia burgdorferi. PLoS Pathog. 2020;16(5):e1008423. Published 2020 May 4. doi:10.1371/journal.ppat.1008423
- Xie J, Zhi H, Garrigues RJ, Keightley A, Garcia BL, Skare JT. Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes. PLoS Pathog. 2019;15(3):e1007659. Published 2019 Mar 21. doi:10.1371/journal.ppat.1007659
- Garcia BL, Zhi H, Wager B, Höök M, Skare JT. Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. PLoS Pathog. 2016;12(1):e1005404. Published 2016 Jan 25. doi:10.1371/journal.ppat.1005404
Farida Sohrabji, PhD
f-sohrabji@tamu.edu| 979.436.0335 | Office: MREB, 4102
Research Interest
Neuroinflammation, gut-brain axis
Graduate Program Affiliation
Publications
- Park MJ, Pilla R, Panta A, et al. Reproductive Senescence and Ischemic Stroke Remodel the Gut Microbiome and Modulate the Effects of Estrogen Treatment in Female Rats. Transl Stroke Res. 2020;11(4):812-830. doi:10.1007/s12975-019-00760-5
Jim Song, PhD
jus35@tamu.edu | 979.436.0633 | Office: MREB-II, 3344
Research Interest
Immune regulation
Graduate Program Affiliation
Publications
- Haque M, Lei F, Xiong X, et al. Stem cell-derived tissue-associated regulatory T cells suppress the activity of pathogenic cells in autoimmune diabetes. JCI Insight. 2019;4(7):e126471. Published 2019 Apr 4. doi:10.1172/jci.insight.126471
Vernon Tesh, PhD
vltesh@tamu.edu | 979.436.0357 | Office: MREB-II, 3224A
Research Interest
Shiga toxins
Graduate Program Affiliation
Publications
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Lee MS, Tesh VL. Roles of Shiga Toxins in Immunopathology. Toxins (Basel). 2019;11(4):212. Published 2019 Apr 9. doi:10.3390/toxins11040212
- Park JY, Jeong YJ, Park SK, et al. Shiga Toxins Induce Apoptosis and ER Stress in Human Retinal Pigment Epithelial Cells. Toxins (Basel). 2017;9(10):319. Published 2017 Oct 13. doi:10.3390/toxins9100319
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Lee MS, Kwon H, Lee EY, et al. Shiga Toxins Activate the NLRP3 Inflammasome Pathway To Promote Both Production of the Proinflammatory Cytokine Interleukin-1β and Apoptotic Cell Death. Infect Immun. 2015;84(1):172-186. Published 2015 Oct 26. doi:10.1128/IAI.01095-15
Robert Watson, Phd, MPH
robert.watson@tamu.edu | 979.436.0342 | Office: MREB, 3100
Research Interest
How the innate immune system interfaces with intracellular bacterial pathogens
Graduate Program Affiliation
Publications
- Weindel CG, Bell SL, Vail KJ, West KO, Patrick KL, Watson RO. LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis. Elife. 2020;9:e51071. Published 2020 Feb 14. doi:10.7554/eLife.51071
- Hoffpauir CT, Bell SL, West KO, et al. TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection. J Immunol. 2020;205(1):153-167. doi:10.4049/jimmunol.1901511
- West KO, Scott HM, Torres-Odio S, West AP, Patrick KL, Watson RO. The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages. Cell Rep. 2019;29(6):1594-1609.e5. doi:10.1016/j.celrep.2019.09.078
Phillip West, PhD
awest@tamu.edu | 979.436.0870 | Office: MREB, 3012
Research Interest
Mitochondrial control of innate immunity and inflammation in health and disease
Graduate Program Affiliation
Publications
- West AP. Mitochondrial dysfunction as a trigger of innate immune responses and inflammation. Toxicology. 2017;391:54-63. doi:10.1016/j.tox.2017.07.016
- West AP, Shadel GS. Mitochondrial DNA in innate immune responses and inflammatory pathology. Nat Rev Immunol. 2017;17(6):363-375. doi:10.1038/nri.2017.21
- West AP, Khoury-Hanold W, Staron M, et al. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 2015;520(7548):553-557. doi:10.1038/nature14156
Yi Xu, PhD
yi-xu1@tamu.edu | 979.436.0568 | Office: ALKEK
Research Interest
Elucidating the molecular interactions between bacterial pathogen and the host
Graduate Program Affiliation
Publications
- Kumar, R., Herold, J.L., Taylor, J. et al. Variations among Streptococcus gallolyticus subsp. gallolyticus strains in connection with colorectal cancer. Sci Rep 8, 1514 (2018). https://doi.org/10.1038/s41598-018-19941-7
- Kumar R, Herold JL, Schady D, et al. Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development. PLoS Pathog. 2017;13(7):e1006440. Published 2017 Jul 13. doi:10.1371/journal.ppat.1006440
- Wang Y, Jenkins SA, Gu C, et al. Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence [published correction appears in PLoS Pathog. 2016 Oct 13;12 (10 ):e1005968] [published correction appears in PLoS Pathog. 2019 Feb 8;15(2):e1007579]. PLoS Pathog. 2016;12(6):e1005678. Published 2016 Jun 15. doi:10.1371/journal.ppat.1005678
Keith Young, PhD
kayoung@tamu.edu | 254.760.5568 | Office: MREB-II, 2310
Research Interests
Blood and brain inflammation, B-cell trafficking to brain
Graduate Program Affiliation
Publications
- Gadad, Bharathi & Li, Wenhao & Yazdani, Umar & Grady, Stephen & Johnson, Trevor & Hammond, Jacob & Gunn, Howard & Curtis, Britni & English, Chris & Yutuc, Vernon & Ferrier, Clayton & Sackett, Gene & Marti, C. & Young, Keith & Hewitson, Laura & German, Dwight. (2015). Administration of thimerosal-containing vaccines to infant rhesus macaques does not result in autism-like behavior or neuropathology. Proceedings of the National Academy of Sciences of the United States of America. 112. 12498-12503. 10.1073/pnas.1500968112.
David Zawieja, PhD
dcz@tamu.edu | 979.436.0829 | Office: MREB-II, 1341
Research Interest
Role of lymphatic function in inflammation and immunity
Graduate Program Affiliation
Publications
- Clement CC, Wang W, Dzieciatkowska M, et al. Quantitative Profiling of the Lymph Node Clearance Capacity. Sci Rep. 2018;8(1):11253. Published 2018 Jul 26. doi:10.1038/s41598-018-29614-0
- Narayanan SA, Metzger CE, Bloomfield SA, Zawieja DC. Inflammation-induced lymphatic architecture and bone turnover changes are ameliorated by irisin treatment in chronic inflammatory bowel disease. FASEB J. 2018;32(9):4848-4861. doi:10.1096/fj.201800178R
- Bridenbaugh EA, Wang W, Srimushnam M, et al. An immunological fingerprint differentiates muscular lymphatics from arteries and veins. Lymphat Res Biol. 2013;11(3):155-171. doi:10.1089/lrb.2013.0023
Keywords: infection; inflammation; microbial pathogenesis; bacteriology; virology; immunology; cytokines; chemokines; phagocytes (macrophages, neutrophils, dendritic cells); complement; wound healing; mesenchymal stem cells