Biomedical Engineering and Regenerative Medicine
Biomedical Engineering and Regenerative Medicine - BERM
Research that explores the potential of somatic stem cells to ameliorate and cure a broad range of diseases.
Faculty
Kayla Bayless, PhD
kaylajb@tamu.edu | 979.436.0763 | Office: MREB-II, 4412, Bryan Campus.
Research Interest
Developing effective protein-based biomaterials to promote neovascularization in diabetic wounds
Graduate Program Affiliation
Publications
- Howell DW, Duran CL, Tsai SP, Bondos SE, Bayless KJ. Functionalization of Ultrabithorax Materials with Vascular Endothelial Growth Factor Enhances Angiogenic Activity. Biomacromolecules. 2016;17(11):3558-3569. doi:10.1021/acs.biomac.6b01068
- Howell DW, Tsai SP, Churion K, et al. Identification of multiple dityrosine bonds in materials composed of the Drosophila protein Ultrabithorax. Adv Funct Mater. 2015;25(37):5988-5998. doi:10.1002/adfm.201502852
- Patterson JL, Abbey CA, Bayless KJ, Bondos SE. Materials composed of the Drosophila melanogaster protein ultrabithorax are cytocompatible. J Biomed Mater Res A. 2014;102(1):97-104. doi:10.1002/jbm.a.34675
Sarah Bondos, PhD
bondos@tamu.edu | 979.436.0807 | Office: MREB-II, 4417, Bryan Campus.
Research Interest
Protein-based biomaterials
Graduate Program Affiliation
Publications
- Mendes GG, Booth RM, Pattison DL, Alvarez AJ, Bondos SE. Generating Novel Materials Using the Intrinsically Disordered Protein Ubx. Methods Enzymol. 2018;611:583-605. doi:10.1016/bs.mie.2018.08.007
- Hsiao HC, Santos A, Howell DW, Patterson JL, Fuchs-Young RS, Bondos SE. Culture of Tumorigenic Cells on Protein Fibers Reveals Metastatic Cell Behaviors. Biomacromolecules. 2016;17(11):3790-3799. doi:10.1021/acs.biomac.6b01311
- Howell DW, Tsai SP, Churion K, et al. Identification of multiple dityrosine bonds in materials composed of the Drosophila protein Ultrabithorax. Adv Funct Mater. 2015;25(37):5988-5998. doi:10.1002/adfm.201502852
Carolyn Cannon, MD, PhD
carolyn.cannon@tamu.edu | 832.822.3300 | Office: MREB-II, 3342, Bryan Campus.
Research Interests
Nanoparticle and electrospun membrane drug delivery devices to treat MDR bacterial infections
Graduate Program Affiliation
Publications
- Chen Q, Shah KN, Zhang F, et al. Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa. Mol Pharm. 2019;16(4):1606-1619. doi:10.1021/acs.molpharmaceut.8b01288
- Zhang F, Smolen JA, Zhang S, et al. Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections. Nanoscale. 2015;7(6):2265-2270. doi:10.1039/c4nr07103d
- Ornelas-Megiatto C, Shah PN, Wich PR, et al. Aerosolized antimicrobial agents based on degradable dextran nanoparticles loaded with silver carbene complexes. Mol Pharm. 2012;9(11):3012-3022. doi:10.1021/mp3004379
Zhilei Chen, PhD
zchen4@tamu.edu | 979.436.9404 | Office: MREB-II, 3325, Bryan Campus.
Research Interest
Therapeutic protein engineering
Graduate Program Affiliation
Publications
- Selection and characterization of ultra-high potency designed ankyrin repeat protein inhibitors of C. difficile toxin B
- De Novo Isolation & Affinity Maturation of Yeast-Displayed Virion-binding Human Fibronectin Domains by Flow Cytometric Screening Against Virions
- Golden Gate Assembly With a Bi-Directional Promoter (GBid): A Simple, Scalable Method for Phage Display Fab Library Creation
Paul Derry, PhD
derry@tamu.edu | 713.677.7515 | Office: ALKEK, 1004A, Houston Campus.
Research Interest
The therapeutic potential of catalytic nanomaterials
Graduate Program Affiliation
Publications
- Fabian RH, Derry PJ, Rea HC, et al. Efficacy of Novel Carbon Nanoparticle Antioxidant Therapy in a Severe Model of Reversible Middle Cerebral Artery Stroke in Acutely Hyperglycemic Rats. Front Neurol. 2018;9:199. Published 2018 Apr 9. doi:10.3389/fneur.2018.00199
- Derry PJ , Nilewski LG , Sikkema WKA , et al. Catalytic oxidation and reduction reactions of hydrophilic carbon clusters with NADH and cytochrome C: features of an electron transport nanozyme. Nanoscale. 2019;11(22):10791-10807. doi:10.1039/c9nr00807a
- Nilewski L, Mendoza K, Jalilov AS, et al. Highly Oxidized Graphene Quantum Dots from Coal as Efficient Antioxidants. ACS Appl Mater Interfaces. 2019;11(18):16815-16821. doi:10.1021/acsami.9b01082
Cedric Geoffroy, PhD
geoffroy@tamu.edu | 979.436.9023 | Office: MREB, 4100, Bryan Campus.
Research Interest
Gene therapy, drug discovery
Graduate Program Affiliation
Publications
- Meves JM, Geoffroy CG, Kim ND, Kim JJ, Zheng B. Oligodendrocytic but not neuronal Nogo restricts corticospinal axon sprouting after CNS injury. Exp Neurol. 2018;309:32-43. doi:10.1016/j.expneurol.2018.07.013
- Chen M, Geoffroy CG, Meves JM, et al. Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS. Cell Rep. 2018;22(13):3587-3597. doi:10.1016/j.celrep.2018.02.102
- Poplawski GHD, Lie R, Hunt M, et al. Adult rat myelin enhances axonal outgrowth from neural stem cells. Sci Transl Med. 2018;10(442):eaal2563. doi:10.1126/scitranslmed.aal2563
Carl Gregory, PhD
cgregory@tamu.edu | 979.463.9643 | Office: MREB-II, 4414, Bryan Campus.
Research Interest
Mesenchymal stem cells, osteochondral tissue engineering
Graduate Program Affiliation
Publications
- Krause U, Harris S, Green A, et al. Pharmaceutical modulation of canonical Wnt signaling in multipotent stromal cells for improved osteoinductive therapy. Proc Natl Acad Sci U S A. 2010;107(9):4147-4152. doi:10.1073/pnas.0914360107
- Zeitouni S, Krause U, Clough BH, et al. Human mesenchymal stem cell-derived matrices for enhanced osteoregeneration [published correction appears in Sci Transl Med. 2012 Aug 29;4(149):149er5]. Sci Transl Med. 2012;4(132):132ra55. doi:10.1126/scitranslmed.3003396
- McNeill EP, Zeitouni S, Pan S, et al. Characterization of a pluripotent stem cell-derived matrix with powerful osteoregenerative capabilities. Nat Commun. 2020;11(1):3025. Published 2020 Jun 15. doi:10.1038/s41467-020-16646-2
Thomas Kent, MD
tkent@tamu.edu | 713.677.7523 | Office: ALKEK, 1004A, Houston Campus.
Research Interest
Therapeutic carbon nanoparticles, nanomedicine, nanozymes
Graduate Program Affiliation
Publications
- Samuel EL, Marcano DC, Berka V, et al. Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters. Proc Natl Acad Sci U S A. 2015;112(8):2343-2348. doi:10.1073/pnas.1417047112
- Palejwala AH, Fridley JS, Mata JA, et al. Biocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in rats. Surg Neurol Int. 2016;7:75. Published 2016 Aug 23. doi:10.4103/2152-7806.188905
- Wu G, Berka V, Derry PJ, et al. Critical Comparison of the Superoxide Dismutase-like Activity of Carbon Antioxidant Nanozymes by Direct Superoxide Consumption Kinetic Measurements. ACS Nano. 2019;13(10):11203-11213. doi:10.1021/acsnano.9b04229
Lih Kuo, PhD
lkuo@tamu.edu | 979.436.9262 | Office: Reynolds, 242B, Bryan Campus.
Research Interest
Vessel Engineering; Vascular Modeling; Nanotechnology
Graduate Program Affiliation
Publications
- Lee P-H, Tsai SH, Kuo L, Hwang C-Y, Kuo C-Y, Yang VC, Chen JK. A prototype tissue engineered blood vessel using amniotic membrane as scaffold. Acta Biomater 8:3342-3348, 2012.
- Mehra NK, Cai D, Kuo L, Hein TW, Palakurthi S. Safety and toxicity of nanomaterials for ocular drug delivery applications. Nanotoxicology 10:836-860, 2016.
- Huang K-T, Han TH, Hyduke DR, Vaughn MW, Van Herle H, Hein TW, Zhang C, Kuo L, Liao JC. Modulation of nitric oxide bioavailability by erythrocytes. Proc Natl Acad Sci USA 98:11771-11776, 2001.
Ryang-Hwa Lee, PhD
rlee@tamu.edu | 979.436.9649 | Office: REYNOLDS, 238, Bryan Campus.
Research Interest
Mesenchymal stem cell-based therapies for tissue repair and autoimmune diseases
Graduate Program Affiliation
Publications
- Kim H, Lee MJ, Bae EH, et al. Comprehensive Molecular Profiles of Functionally Effective MSC-Derived Extracellular Vesicles in Immunomodulation. Mol Ther. 2020;28(7):1628-1644. doi:10.1016/j.ymthe.2020.04.020
- Shigemoto-Kuroda T, Oh JY, Kim DK, et al. MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis. Stem Cell Reports. 2017;8(5):1214-1225. doi:10.1016/j.stemcr.2017.04.008
- Lee RH, Yu JM, Foskett AM, et al. TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo. Proc Natl Acad Sci U S A. 2014;111(47):16766-16771. doi:10.1073/pnas.1416121111
Fei Liu, PhD
fliu@tamu.edu | 979.436.9642 | Office: Reynolds, 242B, Bryan Campus.
Research Interest
Optimization and standardization of mesenchymal stem cells, regeneration of salivary glands
Graduate Program Affiliation
Publications
- MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs
- Inhibition of TGF-β/Smad signaling by BAMBI blocks differentiation of human mesenchymal stem cells to carcinoma-associated fibroblasts and abolished their pro-tumor effects
- Rescue Effects and Underlying Mechanisms of Intra-gland Shh Gene Delivery on Irradiation-Induced Hyposalivation
Samba Reddy, PhD, RPh, FAAPS, FAAAS
sambareddy@tamu.edu | 919.539.8721 | Office: MREB, 2008, Bryan Campus.
Research Interest
Electroceuticals
Graduate Program Affiliation
Publications
- Chuang SH, Reddy DS. Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam. J Pharmacol Exp Ther. 2020;372(3):285-298. doi:10.1124/jpet.119.261735
- Clossen BL, Reddy DS. Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy. Biochim Biophys Acta Mol Basis Dis. 2017;1863(6):1519-1538. doi:10.1016/j.bbadis.2017.02.003
- Reddy SD, Younus I, Sridhar V, Reddy DS. Neuroimaging Biomarkers of Experimental Epileptogenesis and Refractory Epilepsy. Int J Mol Sci. 2019;20(1):220. Published 2019 Jan 8. doi:10.3390/ijms20010220
Lee Shapiro, PhD
lshapiro@tamu.edu | 979.436.0272 | Office: MREB|Bryan Campus
Research Interest
Stem cell therapy to treat brain disorders
Graduate Program Affiliation
Publications
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Arisi GM, Foresti ML, Mukherjee S, Shapiro LA. The role of olfactory stimulus in adult mammalian neurogenesis. Behav Brain Res. 2012;227(2):356-362. doi:10.1016/j.bbr.2011.03.050
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Shapiro LA, Ribak CE. Integration of newly born dentate granule cells into adult brains: hypotheses based on normal and epileptic rodents. Brain Res Brain Res Rev. 2005;48(1):43-56. doi:10.1016/j.brainresrev.2004.08.003
Ashok Shetty, PhD
akskrs@tamu.edu | 979.436.9653 | Office: REYNOLDS, 240A, |Bryan Campus
Research Interest
Stem cells and stem cell-derived extracellular vesicle therapy for neurological disorders
Graduate Program Affiliation
Publications
- Long Q, Upadhya D, Hattiangady B, et al. Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus. Proc Natl Acad Sci U S A. 2017;114(17):E3536-E3545. doi:10.1073/pnas.1703920114
- Kim DK, Nishida H, An SY, Shetty AK, Bartosh TJ, Prockop DJ. Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI. Proc Natl Acad Sci U S A. 2016;113(1):170-175. doi:10.1073/pnas.1522297113
- Hattiangady B, Shetty AK. Neural stem cell grafting counteracts hippocampal injury-mediated impairments in mood, memory, and neurogenesis. Stem Cells Transl Med. 2012;1(9):696-708. doi:10.5966/sctm.2012-0050
Irtisha Singh, PhD
isingh@tamu.edu | 646.574.2080 | Office: MREB-II, Bryan Campus
Research Interest
Biomaterials, tissue engineering
Graduate Program Affiliation
- Medical Science PhD Program
- Interdisciplinary Graduate Program in Genetics
- Biomedical Engineering Graduate Program
Publications
- Carrow JK, Cross LM, Reese RW, et al. Widespread changes in transcriptome profile of human mesenchymal stem cells induced by two-dimensional nanosilicates. Proc Natl Acad Sci U S A. 2018;115(17):E3905-E3913. doi:10.1073/pnas.1716164115
- Carrow JK, Singh KA, Jaiswal MK, et al. Photothermal modulation of human stem cells using light-responsive 2D nanomaterials. Proc Natl Acad Sci U S A. 2020;117(24):13329-13338. doi:10.1073/pnas.1914345117
Jim Song, PhD
jus35@tamu.edu | 979.436.0633 | Office: MREB-II, 3344, Bryan Campus
Research Interest
Stem Cells
Graduate Program Affiliation
Publications
Jun Wang, PhD
jwang188@tamu.edu | 979.436.0389 | Office: MREB, 2106, Bryan Campus
Research Interest
Optogenetics, chemogenetics, confocal imaging, operant conditioning, electrophysiology
Graduate Program Affiliation
- Medical Science PhD Program
- Texas A&M University Institute for Neuroscience
- Texas A&M University Interdisciplinary Faculty of Toxicology
Publications
- Roltsch Hellard E, Binette A, Zhuang X, et al. Optogenetic control of alcohol-seeking behavior via the dorsomedial striatal circuit. Neuropharmacology. 2019;155:89-97. doi:10.1016/j.neuropharm.2019.05.022
- Ma T, Barbee B, Wang X, Wang J. Alcohol induces input-specific aberrant synaptic plasticity in the rat dorsomedial striatum. Neuropharmacology. 2017;123:46-54. doi:10.1016/j.neuropharm.2017.05.014
- Wei X, Ma T, Cheng Y, et al. Dopamine D1 or D2 receptor-expressing neurons in the central nervous system. Addict Biol. 2018;23(2):569-584. doi:10.1111/adb.12512
David Zawieja, PhD
dcz@tamu.edu | 979.436.0829 | Office: MREB-II, 1341 |Bryan Campus
Research Interest
Multiscale computational modeling of lymphatic system function
Graduate Program Affiliation
Publications
- Jafarnejad M, Zawieja DC, Brook BS, Nibbs RJB, Moore JE Jr. A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4. J Immunol. 2017;199(7):2291-2304. doi:10.4049/jimmunol.1700377
- Jamalian S, Davis MJ, Zawieja DC, Moore JE Jr. Network Scale Modeling of Lymph Transport and Its Effective Pumping Parameters. PLoS One. 2016;11(2):e0148384. Published 2016 Feb 4. doi:10.1371/journal.pone.0148384
- Corbo C, Cromer WE, Molinaro R, et al. Engineered biomimetic nanovesicles show intrinsic anti-inflammatory properties for the treatment of inflammatory bowel diseases. Nanoscale. 2017;9(38):14581-14591. doi:10.1039/c7nr04734g
Yubin Zhou, MD, PhD
yubinzhou@tamu.edu | 713.677.7483 | Office: ALKEK, 925, | Houston Campus
Research Interest
Synthetic immunology and intelligent cell-based therapy for cancer and immunoinflammatory disorders
Graduate Program Affiliation
Publications
- Tan P, He L, Han G, Zhou Y. Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity. Trends Biotechnol. 2017;35(3):215-226. doi:10.1016/j.tibtech.2016.09.002
- Yang X, Ma G, Zheng S, et al. Optical Control of CRAC Channels Using Photoswitchable Azopyrazoles. J Am Chem Soc. 2020;142(20):9460-9470. doi:10.1021/jacs.0c02949
- He L, Zhang Y, Ma G, et al. Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation. Elife. 2015;4:e10024. Published 2015 Dec 8. doi:10.7554/eLife.10024
Keywords: Tissue engineering; biomaterials; nanoparticle drug delivery; stem cells; regenerative medicine