Brain, Behavior, Psychiatric and Neurologic Disorders

Brain, Behavior, Psychiatric and Neurologic Disorders - BBPND

Research related to normal neural development and neuro-developmental disorders, behavior, adaptation to injury and disease, psychiatric disorders.

Faculty

Hubert Amrein, PhD

Amrein@tamu.edu | 979.436.0799 | Office: MREB-II, 1348

Research Interest

Internal Nutrient Sensing; Brain-Gut Axis; Glucose Metabolism

Graduate Program Affiliation

Publications

Miyamoto T, Amrein H. Neuronal Gluconeogenesis Regulates Systemic Glucose Homeostasis in Drosophila melanogaster. Curr Biol.2019 Apr 22;29(8):1263-1272
Mishra D, Thorne N, Miyamoto C, Jagge C, Amrein H. The taste of ribonucleosides: Novel macronutrients essential for larval growth are sensed by Drosophila gustatory receptor proteins. PLoS Biol. 2018;16(8):e2005570. Published 2018 Aug 7. doi:10.1371/journal.pbio.2005570
Fujii S, Yavuz A, Slone J, Jagge C, Song X, Amrein H. Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensing. Curr Biol. 2015;25(5):621-627. doi:10.1016/j.cub.2014.12.058

Complete Bibliography

Vytas Bankaitis, PhD

vytas@tamu.edu | 979.436.0757 | Office: REYNOLDS, 116

Research Interest

Neural stem cell biology, neurodegenerative diseases, autism, lipid signaling, lipid metabolism

Graduate Program Affiliation

Publications

Xie Z, Jones A, Deeney JT, Hur SK, Bankaitis VA. Inborn Errors of Long-Chain Fatty Acid β-Oxidation Link Neural Stem Cell Self-Renewal to Autism. Cell Rep. 2016;14(5):991-999. doi:10.1016/j.celrep.2016.01.004
Xie Z, Hur SK, Zhao L, Abrams CS, Bankaitis VA. A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis. Dev Cell. 2018;44(6):725-740.e4. doi:10.1016/j.devcel.2018.02.025
Bankaitis VA, Xie Z. The neural stem cell/carnitine malnutrition hypothesis: new prospects for effective reduction of autism risk?. J Biol Chem. 2019;294(50):19424-19435. doi:10.1074/jbc.AW119.008137

Complete Bibliography

Adam Case, PhD

acase@tamu.edu | 979.436.0757 | Office: REYNOLDS, 116

Research Interest

Cross-talk between the immune system and the brain in mental health disorders

Graduate Program Affiliation

Publications

Moshfegh CM, Elkhatib SK, Collins CW, Kohl AJ, Case AJ. Autonomic and Redox Imbalance Correlates With T-Lymphocyte Inflammation in a Model of Chronic Social Defeat Stress. Front Behav Neurosci. 2019 May 14;13:103. doi: 10.3389/fnbeh.2019.00103. PMID: 31139062; PMCID: PMC6527882.
Elkhatib SK, Moshfegh CM, Watson GF, Case AJ. Peripheral inflammation is strongly linked to elevated zero maze behavior in repeated social defeat stress. Brain Behav Immun. 2020 Nov;90:279-285. doi: 10.1016/j.bbi.2020.08.031. Epub 2020 Sep 3. PMID: 32890698; PMCID: PMC7568442.
Safwan K. Elkhatib, Cassandra M. Moshfegh, Gabrielle F. Watson, Aaron D. Schwab, Kenichi Katsurada, Kaushik P. Patel, Adam J. Case. Splenic denervation attenuates repeated social defeat stress-induced T-lymphocyte inflammation. BioRxiv 2021.01.16.426952; doi: https://doi.org/10.1101/2021.01.16.426952

Complete Bibliography

Jiang Chang, MD, PhD

jiangchang@tamu.edu | 713.677.7603 | Office: ALKEK, 820F

Research Interest

Hydrocephalus, PTSD, biomarkers

Graduate Program Affiliation

Medical Science PhD Program

Publications

Lin X, Liu B, Yang X, et al. Genetic deletion of Rnd3 results in aqueductal stenosis leading to hydrocephalus through up-regulation of Notch signaling. Proc Natl Acad Sci U S A. 2013;110(20):8236-8241. doi:10.1073/pnas.1219995110

Complete Bibliography

Shaunna Clark, PhD

slclark@tamu.edu | 979.436.0179

Research Interest

Genetic and epigenetic basis of addiction and mental health; Statistical methods development

Graduate Program Affiliation

Publications

Clark SL, Hattab MW, Chan RF, et al. A methylation study of long-term depression risk. Mol Psychiatry. 2020;25(6):1334-1343. doi:10.1038/s41380-019-0516-z
Clark SL, Costin BN, Chan RF, et al. A Whole Methylome Study of Ethanol Exposure in Brain and Blood: An Exploration of the Utility of Peripheral Blood as Proxy Tissue for Brain in Alcohol Methylation Studies. Alcohol Clin Exp Res. 2018;42(12):2360-2368. doi:10.1111/acer.13905
Clark SL, Gillespie NA, Adkins DE, Kendler KS, Neale MC. Psychometric modeling of abuse and dependence symptoms across six illicit substances indicates novel dimensions of misuse. Addict Behav. 2016;53:132-140. doi:10.1016/j.addbeh.2015.10.015

Complete Bibliography

Paul Derry, PhD

derry@tamu.edu | 713.677.7515 | Office: ALKEK, 1004A

Research Interest

Neuroprotective antioxidant nanomaterials and iron-mediated neurotoxicity

Graduate Program Affiliation

Medical Science PhD Program

Publications

Derry PJ, Hegde ML, Jackson GR, et al. Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective. Prog Neurobiol. 2020;184:101716. doi:10.1016/j.pneurobio.2019.101716
Dharmalingam P, Talakatta G, Mitra J, et al. Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle. ACS Nano. 2020;14(3):2827-2846. doi:10.1021/acsnano.9b05821
Mendoza K, Derry PJ, Cherian LM, et al. Functional and Structural Improvement with a Catalytic Carbon Nano-Antioxidant in Experimental Traumatic Brain Injury Complicated by Hypotension and Resuscitation. J Neurotrauma. 2019;36(13):2139-2146. doi:10.1089/neu.2018.6027

Complete Bibliography

David Earnest, PhD

dearnest@tamu.edu | 979.436.0328 | Office: MREB, 2004

Research Interest

Role of circadian rhythm disruption in human health disorders (cancer, metabolic disease, stroke)

Graduate Program Affiliation

Center for Biological Clocks Research

Publications

Earnest, D.J., Neuendorff, N., Coffman, J., Selvamani, A. and Sohrabji, F. (2016) Sex differences in the impact of shift work schedules on pathological outcomes in an animal model of ischemic stroke. Endocrinology 157(7): 2836–2843.
Kim,S.-M., Neuendorff, N., Alaniz, R.C., Sun, Y., Chapkin, R.S. and Earnest, D.J. (2018) Shift work cycle-induced alterations of circadian rhythms potentiate the effects of high fat diet on inflammation and metabolism. FASEB J 2: 3085-3095. doi: 0.1096/fj.201700784R.

Complete Bibliography

Cedric Geoffroy, PhD

geoffroy@tamu.edu | 979.436.9023 | Office: MREB, 4100

Research Interest

Spinal cord injury, neurotrauma

Graduate Program Affiliation

Publications

Sutherland TC, Geoffroy CG. The Influence of Neuron-Extrinsic Factors and Aging on Injury Progression and Axonal Repair in the Central Nervous System. Front Cell Dev Biol. 2020;8:190. Published 2020 Mar 25. doi:10.3389/fcell.2020.00190
Geoffroy CG, Hilton BJ, Tetzlaff W, Zheng B. Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System. Cell Rep. 2016;15(2):238-246. doi:10.1016/j.celrep.2016.03.028

Complete Bibliography

John Hettema, MD, PhD

hettema@tamu.edu | 804.516.3276

Research Interest

Developmental mechanisms of anxiety and related disorders

Graduate Program Affiliation

Publications

Hettema JM, Bourdon JL, Sawyers C, et al. Genetic and environmental risk structure of internalizing psychopathology in youth. Depress Anxiety. 2020;37(6):540-548. doi:10.1002/da.23024
Rappaport LM, Carney DM, Brotman MA, et al. A Population-Based Twin Study of Childhood Irritability and Internalizing Syndromes. J Clin Child Adolesc Psychol. 2020;49(4):524-534. doi:10.1080/15374416.2018.1514612
Rappaport LM, Carney DM, Verhulst B, et al. A Developmental Twin Study of Emotion Recognition and Its Negative Affective Clinical Correlates. J Am Acad Child Adolesc Psychiatry. 2018;57(12):925-933.e3. doi:10.1016/j.jaac.2018.05.028

Complete Bibliography

Michelle Hook, PhD

michellehook@tamu.edu | 979.436.0568

Research Interest

Recovery of function following a spinal cord injury (SCI).

Graduate Program Affiliation

Publications

Hook MA, Woller SA, Bancroft E, et al. Neurobiological Effects of Morphine after Spinal Cord Injury. J Neurotrauma. 2017;34(3):632-644. doi:10.1089/neu.2016.4507
Brakel K, Aceves AR, Aceves M, Hierholzer A, Nguyen QN, Hook MA. Depression-like behavior corresponds with cardiac changes in a rodent model of spinal cord injury. Exp Neurol. 2019;320:112969. doi:10.1016/j.expneurol.2019.112969
Luedtke K, Bouchard SM, Woller SA, Funk MK, Aceves M, Hook MA. Assessment of depression in a rodent model of spinal cord injury. J Neurotrauma. 2014;31(12):1107-1121. doi:10.1089/neu.2013.3204

Complete Bibliography

Thomas Kent, MD

tkent@tamu.edu | 713.677.7523 | Office: ALKEK, 1004

Research Interest

Stroke, trauma, neurodegeneration, nanomedicine

Graduate Program Affiliation

Medical Science PhD Program

Publications

Dharmalingam P, Talakatta G, Mitra J, et al. Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle. ACS Nano. 2020;14(3):2827-2846. doi:10.1021/acsnano.9b05821
Mendoza K, Derry PJ, Cherian LM, et al. Functional and Structural Improvement with a Catalytic Carbon Nano-Antioxidant in Experimental Traumatic Brain Injury Complicated by Hypotension and Resuscitation. J Neurotrauma. 2019;36(13):2139-2146. doi:10.1089/neu.2018.6027
Derry PJ, Hegde ML, Jackson GR, et al. Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective. Prog Neurobiol. 2020;184:101716. doi:10.1016/j.pneurobio.2019.101716

Complete Bibliography

Julian Leibowitz, MD, PhD

jleibowitz@tamu.edu | 979.436.0313 | Office: MREB-II, 3224C

Research Interest

Persistent infections of the CNS by coronaviruses and Theiler's murine encephalomyelitis virus

Graduate Program Affiliation

Publications

Bijalwan M, Young CR, Tingling J, et al. Characterization of Plaque-Sized Variants of Daniel's (DA) Strain in Theiler's Virus-Induced Epilepsy. Sci Rep. 2019;9(1):3444. Published 2019 Mar 5. doi:10.1038/s41598-019-38967-z
Oleszak EL, Leibowitz JL, Rodriguez M. Isolation and characterization of two plaque size variants of Theiler's murine encephalomyelitis virus (DA strain). J Gen Virol. 1988;69 ( Pt 9):2413-2418. doi:10.1099/0022-1317-69-9-2413
Rodriguez M, Pavelko KD, McKinney CW, Leibowitz JL. Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis. J Immunol. 1994;153(8):3811-3821.

Complete Bibliography

Rajesh Miranda, PhD

rmiranda@tamu.edu | 979.436.0332 | Office: MREB

Research Interest

Fetal brain development, ncRNAs, neural stem cells

Graduate Program Affiliation

Publications

Tseng AM, Chung DD, Pinson MR, Salem NA, Eaves SE, Miranda RC. Ethanol Exposure Increases miR-140 in Extracellular Vesicles: Implications for Fetal Neural Stem Cell Proliferation and Maturation. Alcohol Clin Exp Res. 2019;43(7):1414-1426. doi:10.1111/acer.14066

Complete Bibliography

Samba Reddy, PhD, RPh, FAAPS, FAAAS

sambareddy@tamu.edu | 919.539.8721 | Office: MREB, 2008

Research Interest

Epilepsy and brain diseases, neurotherapeutics

Graduate Program Affiliation

Publications

Reddy SD, Wu X, Kuruba R, Sridhar V, Reddy DS. Magnetic resonance imaging analysis of long-term neuropathology after exposure to the nerve agent soman: correlation with histopathology and neurological dysfunction [published online ahead of print, 2020 Jul 15]. Ann N Y Acad Sci. 2020;10.1111/nyas.14431. doi:10.1111/nyas.14431
Reddy DS, Estes WA. Clinical Potential of Neurosteroids for CNS Disorders. Trends Pharmacol Sci. 2016;37(7):543-561. doi:10.1016/j.tips.2016.04.003
Younus I, Reddy DS. Epigenetic interventions for epileptogenesis: A new frontier for curing epilepsy. Pharmacol Ther. 2017;177:108-122. doi:10.1016/j.pharmthera.2017.03.002

Complete Bibliography

Mendell Rimer, PhD

rimer@tamu.edu | 979.436.0334 | Office: MREB, 4008

Research Interest

Developmental neuroscience, synapse formation, maintenance, and pathology, neuromuscular diseases

Graduate Program Affiliation

Publications

Rimer M. Extracellular signal-regulated kinases 1 and 2 regulate neuromuscular junction and myofiber phenotypes in mammalian skeletal muscle. Neurosci Lett. 2020;715:134671. doi:10.1016/j.neulet.2019.134671
Seaberg B, Henslee G, Wang S, Paez-Colasante X, Landreth GE, Rimer M. Muscle-derived extracellular signal-regulated kinases 1 and 2 are required for the maintenance of adult myofibers and their neuromuscular junctions. Mol Cell Biol. 2015;35(7):1238-1253. doi:10.1128/MCB.01071-14
Paez-Colasante X, Seaberg B, Martinez TL, Kong L, Sumner CJ, Rimer M. Improvement of neuromuscular synaptic phenotypes without enhanced survival and motor function in severe spinal muscular atrophy mice selectively rescued in motor neurons. PLoS One. 2013;8(9):e75866. Published 2013 Sep 23. doi:10.1371/journal.pone.0075866

Complete Bibliography

Lee Shapiro, PhD

lshapiro@tamu.edu | 979.436.0272 | Office: MREB

Research Interest

Traumatic brain injury, epilepsy, neuroinflammation, immunology, neuroanatomy, neurogenesis, glia

Graduate Program Affiliation

Publications

Tobin RP, Mukherjee S, Kain JM, et al. Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration. Acta Neuropathol Commun. 2014;2:143. Published 2014 Oct 20. doi:10.1186/s40478-014-0143-5
Shapiro LA, Ribak CE. Integration of newly born dentate granule cells into adult brains: hypotheses based on normal and epileptic rodents. Brain Res Brain Res Rev. 2005;48(1):43-56. doi:10.1016/j.brainresrev.2004.08.003
Ribak CE, Shapiro LA, Perez ZD, Spigelman I. Microglia-associated granule cell death in the normal adult dentate gyrus. Brain Struct Funct. 2009;214(1):25-35. doi:10.1007/s00429-009-0231-7

Ashok Shetty, PhD

akskrs@tamu.edu | 979.436.9653 | Office: REYNOLDS, 240A

Research Interest

Traumatic brain injury, epilepsy, AD & Gulf War illness: pathophysiology & therapeutic strategies

Graduate Program Affiliation

Publications

Upadhya D, Hattiangady B, Castro OW, et al. Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration. Proc Natl Acad Sci U S A. 2019;116(1):287-296. doi:10.1073/pnas.1814185115
Shetty AK, Attaluri S, Kodali M, et al. Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro- and systemic inflammation in a model of Gulf War Illness. Redox Biol.
Kodali M, Megahed T, Mishra V, Shuai B, Hattiangady B, Shetty AK. Voluntary Running Exercise-Mediated Enhanced Neurogenesis Does Not Obliterate Retrograde Spatial Memory. J Neurosci. 2016;36(31):8112-8122. doi:10.1523/JNEUROSCI.0766-16.2016

Complete Bibliography

Laura Smith, PhD

laura.smith@tamu.edu | 979.436.0303 | Office: MREB, 4104

Research Interest

Regulation of synapse plasticity in striatum and neuropsychiatric disorders

Graduate Program Affiliation

Publications

Ma T, Huang Z, Xie X, Cheng Y, Zhuang X, Childs MJ, Gangal H, Wang X, Smith LN, Smith RJ, Zhou Y, Wang J. Chronic alcohol drinking persistently suppresses thalamostriatal excitation of cholinergic neurons to impair cognitive flexibility. J Clin Invest. 2022 Feb 15;132(4). doi: 10.1172/JCI154969. PubMed PMID: 34941575; PubMed Central PMCID: PMC8843706.
Huebschman JL, Davis MC, Tovar Pensa C, Guo Y, Smith LN. The fragile X mental retardation protein promotes adjustments in cocaine self-administration that preserve reinforcement level. Eur J Neurosci. 2021 Aug;54(3):4920-4933. doi:10.1111/ejn.15356. Epub 2021 Jun 28. PubMed PMID: 34133054.
Huebschman JL, Corona KS, Guo Y, Smith LN. The Fragile X Mental Retardation Protein Regulates Striatal Medium Spiny Neuron Synapse Density and Dendritic Spine Morphology. Front Mol Neurosci. 2020;13:161. doi: 10.3389/fnmol.2020.00161. eCollection 2020. PubMed PMID: 33013316; PubMed Central PMCID: PMC7511717.

Complete Bibliography

Farida Sohrabji, PhD

f-sohrabji@tamu.edu | 979.436.0335 | Office: MREB, 4102

Research Interest

Sex differences, women's health, gut-brain axis, stroke, Alzhiemer's disease

Graduate Program Affiliation

Publications

Panta A, Pandey S, Duncan IN, Duhamel S, Sohrabji F. Mir363-3p attenuates post-stroke depressive-like behaviors in middle-aged female rats. Brain Behav Immun. 2019;78:31-40. doi:10.1016/j.bbi.2019.01.003

Complete Bibliography

Rahul Srinivasan, PhD

rahul@tamu.edu | 979.436.0289 | Office: MREB, 4012

Research Interest

The role of astrocytes in Parkinson's disease and clinically translatable therapies for Parkinson's

Graduate Program Affiliation

Publications

Srinivasan R, Henley BM, Henderson BJ, et al. Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons. J Neurosci. 2016;36(1):65-79. doi:10.1523/JNEUROSCI.2126-15.2016
Srinivasan R, Henderson BJ, Lester HA, Richards CI. Pharmacological chaperoning of nAChRs: a therapeutic target for Parkinson's disease. Pharmacol Res. 2014;83:20-29. doi:10.1016/j.phrs.2014.02.005
Srinivasan R, Lu TY, Chai H, et al. New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo. Neuron. 2016;92(6):1181-1195. doi:10.1016/j.neuron.2016.11.030

Complete Bibliography

Robert Tsai, MD, PhD

robtsai@tamu.edu | 713.677.7690

Research Interest

Neurodegeneration and regeneration

Graduate Program Affiliation

Medical Science PhD Program

Publications

Tsai RY, McKay RD. A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells. Genes Dev. 2002;16(23):2991-3003. doi:10.1101/gad.55671

Complete Bibliography

Vladimir Vladimirov, MD, PhD

vivladimirov@tamu.edu | 979.436.9708

Research Interest

Molecular pathology of neuropsychiatric disorders

Graduate Program Affiliation

Publications

Vornholt E, Luo D, Qiu W, McMichael GO, Liu Y, Gillespie N, Ma C, Vladimirov VI. Postmortem brain tissue as an underutilized resource to study the molecular pathology of neuropsychiatric disorders across different ethnic populations. Neurosci Biobehav Rev. 2019 Jul;102:195-207. doi: 10.1016/j.neubiorev.2019.04.015. Epub 2019 Apr 24. PMID: 31028758; PMCID: PMC6643003.
Vornholt E, Drake J, Mamdani M, McMichael G, Taylor ZN, Bacanu SA, Miles MF, Vladimirov VI. Identifying a novel biological mechanism for alcohol addiction associated with circRNA networks acting as potential miRNA sponges. Addict Biol. 2021 Nov;26(6):e13071. doi: 10.1111/adb.13071. Epub 2021 Jun 23. PMID: 34164896; PMCID: PMC8590811.
Kim AH, Reimers M, Maher B, Williamson V, McMichael O, McClay JL, van den Oord EJ, Riley BP, Kendler KS, Vladimirov VI. MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders. Schizophr Res. 2010 Dec;124(1-3):183-91. doi: 10.1016/j.schres.2010.07.002. Epub 2010 Aug 2. PMID: 20675101; PMCID: PMC4373420.

Complete Bibliography

Jun Wang, PhD

jwang188@tamu.edu | 979.436.0389 | Office: MREB, 2106

Research Interest

Drug and alcohol addiction, basal ganalia, plasticity, electrophysiology, optogenetics, behavior

Graduate Program Affiliation

Publications

Ma T, Cheng Y, Roltsch Hellard E, Wang X, Lu J, Gao X, Huang CCY, Wei XY, Ji JY, Wang J. Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD. Nat Neurosci. 2018 Mar;21(3):373-383. doi: 10.1038/s****************. Epub 2018 Feb 12. PMID: 29434375; PMCID: PMC5857235.
Cheng Y, Huang CCY, Ma T, et al. Distinct Synaptic Strengthening of the Striatal Direct and Indirect Pathways Drives Alcohol Consumption. Biol Psychiatry. 2017;81(11):918-929. doi:10.1016/j.biopsych.2016.05.016
Wang J, Cheng Y, Wang X, et al. Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum. J Neurosci. 2015;35(33):11634-11643. doi:10.1523/JNEUROSCI.0003-15.2015

Complete Bibliography

Robert Watson, PhD, MPH

robert.watson@tamu.edu | 979.436.0342 | MREB, 3100

Research Interest

Connections between infection, peripheral immune responses, and neuroinflammation

Graduate Program Affiliation

Interdisciplinary Graduate Program in Genetics

Publications

Weindel CG, Bell SL, Vail KJ, West KO, Patrick KL, Watson RO. LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis. Elife. 2020;9:e51071. Published 2020 Feb 14. doi:10.7554/eLife.51071
Patrick KL, Bell SL, Weindel CG, Watson RO. Exploring the "Multiple-Hit Hypothesis" of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat. Front Cell Infect Microbiol. 2019;9:138. Published 2019 May 28. doi:10.3389/fcimb.2019.00138

Complete Bibliography

Gregg Wells, MD, PhD

gbwells@tamu.edu | 979.436.0780 | Office: REYNOLDS, 226

Research Interest

Role of protein structure and function in diseases, particularly in neurological diseases

Graduate Program Affiliation

Texas A&M University Institute for Neuroscience

Publications

Person AM, Wells GB. Characterizing low affinity epibatidine binding to α4β2 nicotinic acetylcholine receptors with ligand depletion and nonspecific binding. BMC Biophys. 2011;4:19. Published 2011 Nov 23. doi:10.1186/2046-1682-4-19
Gallant JR, Traeger LL, Volkening JD, et al. Nonhuman genetics. Genomic basis for the convergent evolution of electric organs. Science. 2014;344(6191):1522-1525. doi:10.1126/science.1254432
Person AM, Bills KL, Liu H, Botting SK, Lindstrom J, Wells GB. Extracellular domain nicotinic acetylcholine receptors formed by alpha4 and beta2 subunits. J Biol Chem. 2005;280(48):39990-40002. doi:10.1074/jbc.M505087200

Complete Bibliography

Keith Young, PhD

kayoung@tamu.edu | 254.760.5568 | Office: MREB-II, 2310

Research Interest

Stereology, PTSD, stress, brain spatial spectroscopy

Graduate Program Affiliation

Texas A&M University Institute for Neuroscience

Publications

Young KA, Thompson PM, Cruz DA, Williamson DE, Selemon LD. BA11 FKBP5 expression levels correlate with dendritic spine density in postmortem PTSD and controls. Neurobiol Stress. 2015;2:67-72. Published 2015 Sep 3. doi:10.1016/j.ynstr.2015.07.002

Complete Bibliography

Yubin Zhou, MD, PhD

yubinzhou@tamu.edu | 713.677.7483 | Office: ALKEK, 925

Research Interest

Neuro-oncology, optogenetics, chemogenetics, and neurodegenerative diseases

Graduate Program Affiliation

Medical Science PhD Program

Publications

Liu Z, Li H, He L, et al. Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma. Cell Chem Biol. 2019;26(3):352-365.e7. doi:10.1016/j.chembiol.2018.11.009
Ma G, Liu J, Ke Y, et al. Optogenetic Control of Voltage-Gated Calcium Channels. Angew Chem Int Ed Engl. 2018;57(24):7019-7022. doi:10.1002/anie.201713080
Lee M, Li J, Liang Y, et al. Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling. J Am Chem Soc. 2017;139(13):4659-4662. doi:10.1021/jacs.7b01459

Complete Bibliography

Keywords: Brain and spinal trauma, cerebrovascular stroke and other neurovascular dysfunction, neuroinflammation, Autism Spectrum Disorders, Fetal Alcohol Spectrum Disorders, neuro-oncology, neuro-muscular disease, autonomic dysfunction, brain-gut and brain-endocrine function, addiction, psychosocial trauma and social determinants of brain health, post-traumatic stress disorder, anxiety disorders, depression, schizophrenia, computational neuroscience, epilepsy, seizures, neurodegenerative diseases including Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA)