Mendell Rimer, PhD
Associate Professor
Contact
Department of Neuroscience & Experimental Therapeutics
8447 John Sharp Pkwy
4008 Medical Research and Education Building
Bryan,
TX
77807
rimer@tamu.edu
Phone: 979.436.0334
Fax: 979.436.0086
Education and Training
- Universidad de Los Andes, Bachelor of Science, Biology
- University of Maryland at Baltimore, Doctor of Philosophy, Molecular and Cell Biology; Minor in Pharmacology
- Stanford University and New York University, Postdoctoral Training in Neurobiology and Molecular Genetics
Research Interests
- Research in the Rimer lab centers on the molecular and cellular mechanisms underlying the formation, maintenance and pathology of synapses, the connections between nerve cells and their targets. Because of its simplicity and experimental accessibility, the lab uses the vertebrate neuromuscular junction (NMJ) as a model system. The NMJ is the synapse between a motor neuron and a skeletal muscle fiber. The lab addresses these problems using state-of-the-art mouse molecular genetic techniques in combination with standard molecular, cellular, and immunological approaches.
- Rimer participates in graduate training as a member of the faculty in the Interdisciplinary Program in Neuroscience and the Medical Science PhD program at Texas A&M University Naresh K. Vashisht College of Medicine.
Representative Publications
Partial Listing. For Complete Listing see: Google Scholar Bio- Lymphatic dysfunction is linked to disease pathogenesis in Duchenne muscular dystrophy animal modelsB Subramanian, S Johnson, A Narayanan, W Wang, BL Seaberg, J Ball, ...Proceedings of the National Academy of Sciences 122 (38), e2505656122 2025
- Mitochondrial DNA damage in substantia nigra pars compacta astrocytes exacerbates dopaminergic neuron loss in a 6-hydroxydopamine mouse model of parkinsonism DA Ayala, GM Hall, E Tijerina, L Lopez, Z Khan, D Paliwal, A Anand, ...bioRxiv, 2025.08. 30.673287 2025
- Lymphatic dysfunction correlates with inflammation in a mouse model of amyotrophic lateral sclerosisA Narayanan, BL Seaberg, A Buxton, A Vernino, VE Williams, ...Disease Models & Mechanisms 18 (7), dmm052148 2025
- Lymphatic Structure and Function Are Associated with Duchenne Muscular Dystrophy PathogenesisS Johnson, B Subramanian, A Narayanan, W Wang, J Ball, JM Rutkowski, ...Physiology 40 (S1), 1870 2025
- Heterogeneous brain region-specific responses to astrocytic mitochondrial DNA damage in mice
DA Ayala, A Matarazzo, BL Seaberg, M Patel, E Tijerina, C Matthews, ...Scientific Reports 14 (1), 18586 2024 - Validation of terminal Schwann cell gene marker expression by fluorescent in situ hybridization using RNAscope BL Seaberg, S Purao, M Rimer Neuroscience letters 771, 136468 2022