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Paul Derry

Paul J. Derry
Paul J. Derry, PhD

Instructional Assistant Professor

Center for Genomic and Precision Medicine

Contact

Translational Medical Sciences
2121 W. Holcombe Blvd
Houston, TX 77030
derry@tamu.edu
Phone: 713.677.7715

Education and Training

  • Austin College, Sherman, BA, 2011
  • Rice University, MS, 2013
  • Rice University, Doctor of Philosophy, 2016
  • Department of Neurology, Baylor College, Postdoctoral, 2017

Research Interests

  • Derry's research focuses on three key areas. First, the redox properties of colloidal carbon nanomaterials derived from materials other than graphene oxide are not well-established. His efforts in this area are to better understand how these materials interact with other reactive species and how they may be applied therapeutically in neurological disease and injury. Second, he studies how nanomaterial synthesis alters the performance of carbon nanomaterials in vitro in models of oxidative stress. Lastly, he is interested in understanding how carbon nanomaterials interact with the mitochondria and if they can be used therapeutically in instances of mitochondrial disease. These projects are part of a larger collaborative effort to design therapeutic carbon nanomaterials from labs throughout the Texas Medical Center: the Tour Lab at Rice University, the Tsai Lab at University of Texas Health Science Center, and the Robertson Lab at Baylor College of Medicine.

Representative Publications

A Complete listing can be found here: https://scholar.google.com/citations?user=hT1EgAgAAAAJ

  • K Mouli, AV Liopo, H Wang, LJ Suva, KR Olson, PJ Derry, TA Kent (2026). SOD1 at the Crossroads: Co-Overexpression of Canonical Antioxidant Response and Noncanonical Hydrogen Sulfide Generation Pathways in Down Syndrome, With Immune Cell Implications 
  • VH Malojirao, AM Mikheev, M Kodavati, AV Liopo, PJ Derry, E Perli, K Mouli, S Zhang, L Zhonglin, T Xiufeng, GW Britz, PJ Horner, TA Kent, ML Hegde (2026). Multifunctional nanozyme therapy accelerates hematoma clearance and attenuates genome damage and senescence after intracerebral hemorrhage. bioRxiv, 2026.03. 12.711396
  • U Khan, K Mouli, A Liopo, P Derry, T Kent (2025). Pleozymes, A Multifunctional Nanozyme for Targeting Metabolic Deficits in Friedreich's Ataxia. MOVEMENT DISORDERS 40
  • JM Tour, L Nilewski, W Sikkema, K MENDOZA, TA Kent, W DALMEIDA Jr, PJ DERRY, AL TSAI, ML HEGDE, P DHARMALINGAM, PD HEGDE, S MITRA, J MITRA (2025). Acute and chronic mitochondrial electron transport chain dysfunction treatments and graphenic materials for use thereof. US Patent 12,329,780
  • K Mouli, A Vo, A Liopo, P Lorenzi, L Tan, B Wei, S Martinez, E Mchugh, J Tour, U Khan, P Derry, T Kent (2025). Pleiotropic Oxidized Carbon Nanozymes Enhance Aerobic and Ketogenic Metabolism In-vitro and In-vivo in Contused Brain. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 45 (1), 258-258
  • VH Malojirao, V Vasquez, M Kodavati, J Mitra, V Provasek, ATT Voh, AV Liopo, PJ Derry, AM Mikheev, RC Rostomily, PJ Horner, JM Tour, GW Britz, TA Kent, ML Hegde(2025).Hemin-induced transient senescence via DNA damage response: a neuroprotective mechanism against ferroptosis in intracerebral hemorrhage. Communications Biology 8 (1), 622
  • K Mouli, AV Liopo, EA McHugh, E Underwood, J Zhao, PK Dash, ATT Voh, VH Malojirao, ML Hegde, JM Tour, PJ Derry, TA Kent (2025). Oxidized carbon nanoparticles enhance cellular energetics with application to injured brain. Advanced Healthcare Materials 14 (8), 2401629
  • Derry, P. J., Nilewski, L. G., Sikkema, W. K. A., Mendoza, K., Jalilov, A., Berka, V., Dalmeida, W. V., Tsai, A-L., Tour, J. M., Kent, T. A. (2019). Catalytic oxidation and reduction reactions of hydrophilic carbon clusters with NADH and cytochrome C: features of an electron transport nanozyme. Nanoscale. 11(22), 10791-10807.
  • Nilewski, L., Mendoza, K. Jalilov, A. S., Berka, V., Wu, G., Sikkema, W. K. A., Metzger, A., Ye, R., Zhang, R., Luong, D. X., Wang, T., McHugh, E. A., Derry, P. J., Samuel, E. L., Kent, T. A., Tour, J. M. (2019). Highly Oxidized Graphene Quantum Dots from Coal as Efficient Antioxidants. ACS Appl. Mater. Interfaces. 11(18), 16815-16821.
  • Mendoza, K.†, Derry, P. J.†, Cherian, L., Garcia, R., Nilewski, L., Goodman, C. J., Mbye, L., Tour, J. M., Kent, T. A. (2018). Improved outcome with a catalytic carbon nano-antioxidant in experimental traumatic brain injury complicated by hypotension. J. Neurotrauma. 36(13), 2139-2146.
  • Fabian, R. H.†, Derry, P. J.†, Rea, H. C., Samuel, E. L., Nilewski, L. G., Sikkema, K. A., Mandava, P., Tsai, A-L., Mendoza, K., Berka, V., Tour, J. M., Kent, T. A. (2018) Efficacy of Novel Carbon Nanoparticle Antioxidant Therapy in a Severe Model of Reversible Middle Cerebral Artery Stroke in Acutely Hyperglycemic Rats. Front. Neurol. 9, 199.

 

https://www.researchgate.net/scientific-contributions/Paul-J-Derry-2132465895