Joseph M. Rutkowski, PhD
Joseph M. Rutkowski, PhD
Associate Professor of Medical Physiology
Director, Division of Lymphatic Biology
Lymphatic vessel biology and physiology; Lymphangiogenesis; Inflammation and immunity; Cardiorenal disease; Lymphedema; Lipedema
Contact
Medical Physiology
8447 Riverside Pkwy
2414 Medical Research and Education Building 2
Bryan,
TX
77807
rutkowski@tamu.edu
Phone: 979.436.0576
Education and Training
- Penn State University, BS, Chemical Engineering, 2001
- Northwestern University, MS, Chemical Engineering, 2003
- École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, PhD, Bioengineering and Biotechnology, 2008
- University of Texas Southwestern Medical Center, Postdoctoral Fellowship, 2012
Research Interests
- As modulator of interstitial flow and molecular transport lymphatic circulation governs tissues homeostasis. We utilize lymphatic physiology in two different ways: first, we address how lymphatic circulation and interstitial flux changes in pathological states and during manipulations to the encompassing cell biology of a given vascularized tissue; second, we employ genetic manipulations of lymphatic endothelial cell biology to quantify effects not only in lymphatic function, but to the tissue's pathology as a whole. Our research approach incorporates a vast array of tools from protein analysis and lipidomics to tissue engineering and transgenic mouse model generation.
- Current ongoing projects are mostly focused on the Lymphatic Physiology of Metabolic Systems. Herein, we are utilizing an extensive toolkit of genetic mouse models and physiologically-relevant in vitro systems to identify how changes in lymphatic biology impact metabolite transport and whole animal metabolism.
- Other projects use our toolkit in identifying factors driving the pathology of lymphatic diseases such as generalized lymphatic anomalies (GLA) and lymphedema. Additional collaborative efforts employ our models in renal and pulmonary health.
Representative Publications
- Creed HA, Sanfelippo AN, Reyna AJ, Chakraborty A, Rutkowski JM. Impact of High Fat Diet and Bolus Feeding on Chyle Accumulation in a Mouse Model of Generalized Lymphatic Anomaly. Lymphat Res Biol. 2021 Nov 8;. doi: 10.1089/lrb.2021.0031. [Epub ahead of print] PubMed PMID: 34748416.
- Chakraborty A, Upadhya R, Usman TA, Shetty AK, Rutkowski JM. Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress. Brain Behav Immun. 2021 Nov;98:219-233. doi: 10.1016/j.bbi.2021.08.007. Epub 2021 Aug 11. PubMed PMID: 34389489; PubMed Central PMCID: PMC8511130.
- Baranwal G, Creed HA, Black LM, Auger A, Quach AM, Vegiraju R, Eckenrode HE, Agarwal A, Rutkowski JM. Expanded renal lymphatics improve recovery following kidney injury. Physiol Rep. 2021 Nov;9(22):e15094. doi: 10.14814/phy2.15094. PubMed PMID: 34806312; PubMed Central PMCID: PMC8606868.
- Baranwal G, Creed HA, Cromer WE, Wang W, Upchurch BD, Smithhart MC, Vadlamani SS, Clark MC, Busbuso NC, Blais SN, Reyna AJ, Dongaonkar RM, Zawieja DC, Rutkowski JM. Dichotomous effects on lymphatic transport with loss of caveolae in mice. Acta Physiol (Oxf). 2021 Aug;232(4):e13656. doi: 10.1111/apha.13656. Epub 2021 Apr 9. PubMed PMID: 33793057; PubMed Central PMCID: PMC8513672.
- Creed HA, Rutkowski JM. Emerging roles for lymphatics in acute kidney injury: Beneficial or maleficent?. Exp Biol Med (Maywood). 2021 Apr;246(7):845-850. doi: 10.1177/1535370220983235. Epub 2021 Jan 19. PubMed PMID: 33467886; PubMed Central PMCID: PMC8719026.
- Balasubbramanian D, Baranwal G, Clark MC, Goodlett BL, Mitchell BM, Rutkowski JM. Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice. J Hypertens. 2020 May;38(5):874-885. doi: 10.1097/HJH.0000000000002349. PubMed PMID: 31913221; PubMed Central PMCID: PMC7754173.
- Chakraborty A, Scogin CK, Rizwan K, Morley TS, Rutkowski JM. Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D. Front Physiol. 2020;11:363. doi: 10.3389/fphys.2020.00363. eCollection 2020. PubMed PMID: 32390866; PubMed Central PMCID: PMC7188984.
- Chakraborty A, Barajas S, Lammoglia GM, Reyna AJ, Morley TS, Johnson JA, Scherer PE, Rutkowski JM. Vascular Endothelial Growth Factor-D (VEGF-D) Overexpression and Lymphatic Expansion in Murine Adipose Tissue Improves Metabolism in Obesity. Am J Pathol. 2019 Apr;189(4):924-939. doi: 10.1016/j.ajpath.2018.12.008. Epub 2019 Mar 13. PubMed PMID: 30878136; PubMed Central PMCID: PMC6458523.
- Lopez Gelston CA, Balasubbramanian D, Abouelkheir GR, Lopez AH, Hudson KR, Johnson ER, Muthuchamy M, Mitchell BM, Rutkowski JM. Enhancing Renal Lymphatic Expansion Prevents Hypertension in Mice. Circ Res. 2018 Apr 13;122(8):1094-1101. doi: 10.1161/CIRCRESAHA.118.312765. Epub 2018 Feb 23. PubMed PMID: 29475981.
- Lammoglia GM, Van Zandt CE, Galvan DX, Orozco JL, Dellinger MT, Rutkowski JM. Hyperplasia, de novo lymphangiogenesis, and lymphatic regression in mice with tissue-specific, inducible overexpression of murine VEGF-D. Am J Physiol Heart Circ Physiol. 2016 Aug 1;311(2):H384-94. doi: 10.1152/ajpheart.00208.2016. Epub 2016 Jun 24. PubMed PMID: 27342876.
Recent Publications
- Verissimo T, Faivre A, Rinaldi A, Lindenmeyer M, Delitsikou V, Veyrat-Durebex C, Heckenmeyer C, Fernandez M, Berchtold L, Dalga D, Cohen C, Naesens M, Ricksten SE, Martin PY, Pugin J, Merlier F, Haupt K, Rutkowski JM, Moll S, Cippà PE, Legouis D, de Seigneux S. Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease. J Am Soc Nephrol. 2022 Apr;33(4):810-827. doi: 10.1681/ASN.2021050680. Epub 2022 Mar 10. PubMed PMID: 35273087.
- Goodlett BL, Kang CS, Yoo E, Navaneethabalakrishnan S, Balasubbramanian D, Love SE, Sims BM, Avilez DL, Tate W, Chavez DR, Baranwal G, Nabity MB, Rutkowski JM, Kim D, Mitchell BM. A Kidney-Targeted Nanoparticle to Augment Renal Lymphatic Density Decreases Blood Pressure in Hypertensive Mice. Pharmaceutics. 2021 Dec 30;14(1). doi: 10.3390/pharmaceutics14010084. PubMed PMID: 35056980; PubMed Central PMCID: PMC8780399.
- Creed HA, Sanfelippo AN, Reyna AJ, Chakraborty A, Rutkowski JM. Impact of High Fat Diet and Bolus Feeding on Chyle Accumulation in a Mouse Model of Generalized Lymphatic Anomaly. Lymphat Res Biol. 2021 Nov 8;. doi: 10.1089/lrb.2021.0031. [Epub ahead of print] PubMed PMID: 34748416.
- Chakraborty A, Upadhya R, Usman TA, Shetty AK, Rutkowski JM. Chronic VEGFR-3 signaling preserves dendritic arborization and sensitization under stress. Brain Behav Immun. 2021 Nov;98:219-233. doi: 10.1016/j.bbi.2021.08.007. Epub 2021 Aug 11. PubMed PMID: 34389489; PubMed Central PMCID: PMC8511130.
- Baranwal G, Creed HA, Black LM, Auger A, Quach AM, Vegiraju R, Eckenrode HE, Agarwal A, Rutkowski JM. Expanded renal lymphatics improve recovery following kidney injury. Physiol Rep. 2021 Nov;9(22):e15094. doi: 10.14814/phy2.15094. PubMed PMID: 34806312; PubMed Central PMCID: PMC8606868.
- Baranwal G, Pilla R, Goodlett BL, Coleman AK, Arenaz CM, Jayaraman A, Rutkowski JM, Alaniz RC, Mitchell BM. Common Metabolites in Two Different Hypertensive Mouse Models: A Serum and Urine Metabolome Study. Biomolecules. 2021 Sep 21;11(9). doi: 10.3390/biom11091387. PubMed PMID: 34572600; PubMed Central PMCID: PMC8467937.
- Rutkowski JM. Fixing lymphatics improves glucose metabolism. Nat Metab. 2021 Sep;3(9):1139-1141. doi: 10.1038/s42255-021-00442-3. PubMed PMID: 34545252.
- Baranwal G, Creed HA, Cromer WE, Wang W, Upchurch BD, Smithhart MC, Vadlamani SS, Clark MC, Busbuso NC, Blais SN, Reyna AJ, Dongaonkar RM, Zawieja DC, Rutkowski JM. Dichotomous effects on lymphatic transport with loss of caveolae in mice. Acta Physiol (Oxf). 2021 Aug;232(4):e13656. doi: 10.1111/apha.13656. Epub 2021 Apr 9. PubMed PMID: 33793057; PubMed Central PMCID: PMC8513672.
- Creed HA, Rutkowski JM. Emerging roles for lymphatics in acute kidney injury: Beneficial or maleficent?. Exp Biol Med (Maywood). 2021 Apr;246(7):845-850. doi: 10.1177/1535370220983235. Epub 2021 Jan 19. PubMed PMID: 33467886; PubMed Central PMCID: PMC8719026.
- Faivre A, Katsyuba E, Verissimo T, Lindenmeyer M, Rajaram RD, Naesens M, Heckenmeyer C, Mottis A, Feraille E, Cippà P, Cohen C, Longchamp A, Allagnat F, Rutkowski JM, Legouis D, Auwerx J, de Seigneux S. Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease. Nephrol Dial Transplant. 2021 Jan 1;36(1):60-68. doi: 10.1093/ndt/gfaa124. PubMed PMID: 33099633.
- Navaneethabalakrishnan S, Goodlett BL, Lopez AH, Rutkowski JM, Mitchell BM. Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads. Clin Sci (Lond). 2020 Dec 23;134(24):3237-3257. doi: 10.1042/CS20201023. Review. PubMed PMID: 33346358.
- Balasubbramanian D, Baranwal G, Clark MC, Goodlett BL, Mitchell BM, Rutkowski JM. Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice. J Hypertens. 2020 May;38(5):874-885. doi: 10.1097/HJH.0000000000002349. PubMed PMID: 31913221; PubMed Central PMCID: PMC7754173.
- Chakraborty A, Scogin CK, Rizwan K, Morley TS, Rutkowski JM. Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D. Front Physiol. 2020;11:363. doi: 10.3389/fphys.2020.00363. eCollection 2020. PubMed PMID: 32390866; PubMed Central PMCID: PMC7188984.
- Dizin E, Olivier V, Maire C, Komarynets O, Sassi A, Roth I, Loffing J, de Seigneux S, Maillard M, Rutkowski JM, Edwards A, Feraille E. Time-course of sodium transport along the nephron in nephrotic syndrome: The role of potassium. FASEB J. 2020 Feb;34(2):2408-2424. doi: 10.1096/fj.201901345R. Epub 2019 Dec 29. PubMed PMID: 31908015.
- Delitsikou V, Jarad G, Rajaram RD, Ino F, Rutkowski JM, Chen CD, Santos CXC, Scherer PE, Abraham CR, Shah AM, Feraille E, Miner JH, de Seigneux S. Klotho regulation by albuminuria is dependent on ATF3 and endoplasmic reticulum stress. FASEB J. 2020 Feb;34(2):2087-2104. doi: 10.1096/fj.201900893R. Epub 2019 Dec 23. PubMed PMID: 31907991.
- Balasubbramanian D, Gelston CAL, Lopez AH, Iskander G, Tate W, Holderness H, Rutkowski JM, Mitchell BM. Augmenting Renal Lymphatic Density Prevents Angiotensin II-Induced Hypertension in Male and Female Mice. Am J Hypertens. 2020 Jan 1;33(1):61-69. doi: 10.1093/ajh/hpz139. PubMed PMID: 31429865; PubMed Central PMCID: PMC6931897.