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Cédric G. Geoffroy, PhD

Cédric G. Geoffroy
Cédric G. Geoffroy, PhD

Assistant Professor

Contact

Department of Neuroscience & Experimental Therapeutics
4100 Medical Research and Education Building
8447 Riverside Parkway
Bryan, TX 77807
geoffroy@tamu.edu
Phone: 979.436.9023
Fax: 979.436.0086
Lab Website

Education and Training

  • University of Cambridge, UK., PhD
  • Department of Neurosciences, UC San Diego, Postdoctoral
  • Department of Neurosciences, UC San Diego, Assistant Project Scientist

Research Interests

  • The main focus of the laboratory is to better understand the molecular, cellular and physiological changes occurring after neurotrauma, in particular after spinal cord injury (SCI). Indeed, SCI is the second cause of paralysis, following close behind stroke. But besides the direct locomotor impairments, SCI also lead to numerous health complications, including metabolic syndrome, respiratory and cardiovascular problems. These health complications not only threaten patients' lives, but also impact their quality of life. Therefore, one major aim in my lab is to better understand the physiopathology of the SCI and health complications occurring after chronic SCI (in mouse models of SCI). Using genetic and pharmacological approaches, we aim at finding targets that can reduce incidence of these health issues as well as reverse them in more chronic models. The second goal of my lab is to understand how age impacts SCI. Indeed, SCI increasingly afflicts the middle-aged population, as a result of both later average incidence (from ~29 in the 1970s to ~42 since 2010) and aging of SCI-paralyzed patients (~75% of people with SCI are over 40 years old). Recently, we demonstrated that axon regeneration is impaired after injury in older animals. This decline in axon growth can be controlled by both neuronal intrinsic and extrinsic factors. By better understanding the players involved in this age-dependent growth decline, we aim at finding targets to promote axon growth after SCI and ultimately promote locomotor function recovery in the middle-aged population. Technics Molecular biology (PCR, plasmid construction, virus…); biochemistry (western blotting…); genetics (RNA-sequencing, gene-editing, transgenic animals); cell culture (primary cell culture of neurons, astrocytes, macrophages); live cell imaging; flow cytometry; immunocyto- and histochemistry, fluorescent microscopy; small animal surgeries (spinal cord injury models, intraspinal and intracranial microinjections), non-invasive measurements (cardiovascular functions analysis, ultrasound imaging…), locomotor function analysis, drug testing.

Representative Publications