Jeffrey Cirillo, PhD

Biography

 Research Interests : 

• Respiratory infectious diseases from host and pathogen perspective.
• Translational research developing interventions through therapeutics, vaccines and diagnostic technologies.
• Bacterial pathogenesis, host-pathogen interactions at the molecular and cellular level
• Imaging technologies at the whole animal to ultrastructural level.
• Genomics, proteomics, epigenetics, cellular models, animal models, immunology.
• Our laboratory is interested in the pathogenesis of lung infections particularly tuberculosis, Legionnaires' disease, COVID-19 and ESCAPE pathogens (highly drug resistant pathogens) that include Pseudomonas, Klebsiella and Staphylococcus.
• We are examining virulence mechanisms using cellular, molecular and genetic techniques. Our primary research goal is to obtain a better understanding of the roles of the pathogen and host in disease. These studies should contribute to our understanding of host-pathogen interactions at the molecular and cellular level that can be used for development of novel technologies for prevention, treatment and diagnosis.
• We hope that through a better understanding of the mechanisms by which these organisms cause disease we can prevent some, if not all, of these infections in the future.