Kayla Bayless, PhD
Kayla Bayless, PhD
Associate Professor
Contact
Medical Physiology
4412 Medical Research Education Building II
Bryan,
TX
77807
kaylajb@tamu.edu
Phone: 979.436.0763
Fax: 979.847.7287
Education and Training
- Texas Lutheran College, BS, Molecular Biology, 1994
- Texas A&M University College of Medicine, PhD, Medical Physiology, 1999
- Texas A&M University Health Science Center, Post-Doc, Department of Pathology
Research Interests
- The Bayless lab seeks to uncover molecular signals that initiate angiogenesis, the process of new blood vessel formation from existing structures. Endothelial cells line blood vessels and remain dormant for decades but respond rapidly to pro-angiogenic signals and initiate new blood vessel growth. We have shown a variety of cytoskeletal, adaptor and transmembrane proteins are essential for this transition and continue to uncover new molecular pathways using genetic, biochemical, pharmacological, and microscopy techniques.
- We are also actively collaborating with multiple investigators to design biomaterials to promote angiogenesis, along with model systems to study lymphangiogenesis, angiogenic responses to nutraceutical compounds, decidualization, and tumor metastasis.
Representative Publications
- Identification of New Markers of Angiogenic Sprouting Using Transcriptomics: New Role for RND3.Abbey CA, Duran CL, Chen Z, Chen Y, Roy S, Coffell A, Sveeggen TM, Chakraborty S, Wells GB, Chang J, Bayless KJ.Arterioscler Thromb Vasc Biol. 2024 May;44(5):e145-e167. doi: 10.1161/ATVBAHA.123.320599. Epub 2024 Mar 14.PMID: 38482696
- The NADPH oxidase 2 subunit p47phox binds to the WAVE regulatory complex and p22phox in a mutually exclusive manner. Kuihon SVNP, Sevart BJ, Abbey CA, Bayless KJ, Chen B.J Biol Chem. 2024 Apr;300(4):107130. doi: 10.1016/j.jbc.2024.107130. Epub 2024 Mar 1.PMID: 38432630 Free PMC article.
- TWIST1 and TSG6 are coordinately regulated and function as potency biomarkers in human MSCs.
Lee RH, Boregowda SV, Shigemoto-Kuroda T, Bae E, Haga CL, Abbery CA, Bayless KJ, Haskell A, Gregory CA, Ortiz LA, Phinney DG.Sci Adv. 2023 Nov 10;9(45):eadi2387. doi: 10.1126/sciadv.adi2387. Epub 2023 Nov 10.PMID: 37948519 Free PMC article. - Perfusability and immunogenicity of implantable pre-vascularized tissues recapitulating features of native capillary network. Sharma D, Sharma A, Hu L, Chen TA, Voon S, Bayless KJ, Goldman J, Walsh AJ, Zhao F.Bioact Mater. 2023 Aug 11;30:184-199. doi: 10.1016/j.bioactmat.2023.07.023. eCollection 2023 Dec.PMID: 37589031 Free PMC article.
- Direct Involvement of CD8+ T Cells in Retinal Angiogenesis. Bayless KJ.Arterioscler Thromb Vasc Biol. 2023 Apr;43(4):537-539. doi: 10.1161/ATVBAHA.123.319101. Epub 2023 Mar 22.PMID: 36947606 Free article. No abstract available.
- Conjugated Bile Acids Promote Lymphangiogenesis by Modulation of the Reactive Oxygen Species-p90RSK-Vascular Endothelial Growth Factor Receptor 3 Pathway. Banerjee P, Kumaravel S, Roy S, Gaddam N, Odeh J, Bayless KJ, Glaser S, Chakraborty S.Cells. 2023 Feb 6;12(4):526. doi: 10.3390/cells12040526.PMID: 36831193 Free PMC article.
- Annexin A2 modulates phospholipid membrane composition upstream of Arp2 to control angiogenic sprout initiation. Sveeggen TM, Abbey CA, Smith RL, Salinas ML, Chapkin RS, Bayless KJ.FASEB J. 2023 Jan;37(1):e22715. doi: 10.1096/fj.202201088R.PMID: 36527391 Free PMC article.
- MicroRNA-150 (miR-150) and Diabetic Retinopathy: Is miR-150 Only a Biomarker or Does It Contribute to Disease Progression? Ko GY, Yu F, Bayless KJ, Ko ML.Int J Mol Sci. 2022 Oct 11;23(20):12099. doi: 10.3390/ijms232012099.PMID: 36292956 Free PMC article. Review.
- Hypertensive Stimuli Indirectly Stimulate Lymphangiogenesis through Immune Cell Secreted Factors.
Wilcox BK, Henley MR, Navaneethabalakrishnan S, Martinez KA, Pournouri A, Goodlett BL, Lopez AH, Allbee ML, Pickup EJ, Bayless KJ, Chakraborty S, Mitchell BM.Cells. 2022 Jul 7;11(14):2139. doi: 10.3390/cells11142139.PMID: 35883582 Free PMC article. - EZH2 and Endometrial Cancer Development: Insights from a Mouse Model.
Fang X, Ni N, Wang X, Tian Y, Ivanov I, Rijnkels M, Bayless KJ, Lydon JP, Li Q.Cells. 2022 Mar 7;11(5):909. doi: 10.3390/cells11050909.PMID: 35269532 Free PMC article. - Tumor Lymphatic Interactions Induce CXCR2-CXCL5 Axis and Alter Cellular Metabolism and Lymphangiogenic Pathways to Promote Cholangiocarcinoma. Roy S, Kumaravel S, Banerjee P, White TK, O'Brien A, Seelig C, Chauhan R, Ekser B, Bayless KJ, Alpini G, Glaser SS, Chakraborty S.Cells. 2021 Nov 9;10(11):3093. doi: 10.3390/cells10113093.PMID: 34831316 Free PMC article.
- CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function. Mao Y, Kleinjan ML, Jilishitz I, Swaminathan B, Obinata H, Komarova YA, Bayless KJ, Hla T, Kitajewski JK.Sci Signal. 2021 Apr 20;14(679):eabc0425. doi: 10.1126/scisignal.abc0425.PMID: 33879602 Free PMC article.
- Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis. Fu H, Sun Y, Shao Y, Saredy J, Cueto R, Liu L, Drummer C 4th, Johnson C, Xu K, Lu Y, Li X, Meng S, Xue ER, Tan J, Jhala NC, Yu D, Zhou Y, Bayless KJ, Yu J, Rogers TJ, Hu W, Snyder NW, Sun J, Qin X, Jiang X, Wang H, Yang X.Front Immunol. 2020 Oct 14;11:595813. doi: 10.3389/fimmu.2020.595813. eCollection 2020.PMID: 33154757 Free PMC article.
- The β1-integrin plays a key role in LEC invasion in an optimized 3-D collagen matrix model.
Kumaravel S, Abbey CA, Bayless KJ, Chakraborty S.Am J Physiol Cell Physiol. 2020 Dec 1;319(6):C1045-C1058. doi: 10.1152/ajpcell.00299.2020. Epub 2020 Oct 14.PMID: 33052069 Free article. - Transforming growth factor beta signaling and decidual integrity in mice†.
Fang X, Ni N, Gao Y, Lydon JP, Ivanov I, Rijnkels M, Bayless KJ, Li Q.Biol Reprod. 2020 Dec 1;103(6):1186-1198. doi: 10.1093/biolre/ioaa155.PMID: 32902612 Free PMC article. - Hypoxic tumor microenvironment: Implications for cancer therapy.
Roy S, Kumaravel S, Sharma A, Duran CL, Bayless KJ, Chakraborty S.Exp Biol Med (Maywood). 2020 Jul;245(13):1073-1086. doi: 10.1177/1535370220934038. Epub 2020 Jun 27.PMID: 32594767 Free PMC article. Review. - Mechanotransduction drives morphogenesis to develop folding during placental development in pigs.
Seo H, Li X, Wu G, Bazer FW, Burghardt RC, Bayless KJ, Johnson GA.Placenta. 2020 Jan 15;90:62-70. doi: 10.1016/j.placenta.2019.12.011. Epub 2019 Dec 13.PMID: 32056554 - OPN binds alpha V integrin to promote endothelial progenitor cell incorporation into vasculature.
Wing TT, Erikson DW, Burghardt RC, Bazer FW, Bayless KJ, Johnson GA.Reproduction. 2020 Apr;159(4):465-478. doi: 10.1530/REP-19-0358.PMID: 31990676 Free PMC article. - FTY720, a sphingosine analog, altered placentome histoarchitecture in ewes.
Dunlap KA, White BG, Erikson DW, Satterfield MC, Pfarrer C, Wu G, Bazer FW, Burghardt RC, Bayless KJ, Johnson GA.J Anim Sci Biotechnol. 2020 Jan 6;11:2. doi: 10.1186/s40104-019-0411-0. eCollection 2020.PMID: 31911836 Free PMC article. - Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis.
Shi L, Zhao M, Abbey CA, Tsai SH, Xie W, Pham D, Chapman S, Bayless KJ, Hein TW, Rosa RH Jr, Ko ML, Kuo L, Ko GY.J Am Heart Assoc. 2019 Nov 19;8(22):e013673. doi: 10.1161/JAHA.119.013673. Epub 2019 Nov 8.PMID: 31698979 Free PMC article. - Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress. van Engeland NCA, Suarez Rodriguez F, Rivero-Müller A, Ristori T, Duran CL, Stassen OMJA, Antfolk D, Driessen RCH, Ruohonen S, Ruohonen ST, Nuutinen S, Savontaus E, Loerakker S, Bayless KJ, Sjöqvist M, Bouten CVC, Eriksson JE, Sahlgren CM.Sci Rep. 2019 Aug 27;9(1):12415. doi: 10.1038/s41598-019-48218-w.PMID: 31455807 Free PMC article.
- Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity.
Fang X, Ni N, Lydon JP, Ivanov I, Bayless KJ, Rijnkels M, Li Q.Am J Pathol. 2019 Jun;189(6):1212-1225. doi: 10.1016/j.ajpath.2019.02.016. Epub 2019 Apr 5.PMID: 30954472 Free PMC article. - Piezo1 mediates angiogenesis through activation of MT1-MMP signaling.
Kang H, Hong Z, Zhong M, Klomp J, Bayless KJ, Mehta D, Karginov AV, Hu G, Malik AB.Am J Physiol Cell Physiol. 2019 Jan 1;316(1):C92-C103. doi: 10.1152/ajpcell.00346.2018. Epub 2018 Nov 14.PMID: 30427721 Free PMC article.
