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Karienn A. de Souza, PhD

Karienn S. de Souza
Karienn S. de Souza, PhD

Research Assistant Professor

Contact

Department of Neuroscience and Experimental Therapeutics
8447 Riverside Parkway
2112 Medical Research and Education Building
Bryan, TX 77807
karienn@tamu.edu
Phone: 979.436.0271
Fax: 979.436.0086

Education and Training

  • Texas A&M University, BS, Biochemistry, 2006
  • University of Florida, School of Medicine, PhD, Neuroscience, 2012
  • Baylor School of Medicine, Postdoctoral Fellow, 2012-2014
  • Texas A&M Health Science Center, Postdoctoral Fellow, 2015-2019

Research Interests

  • Utilization of optogenetic mouse models to study presynaptic mechanisms related to pathology in the early and pre-symptomatic stages of cognitive impairment.
  • Role of the Immune System and Inflammation in normal cognitive aging.
  • Cognitive and functional outcomes of sleep-wake cycle disturbances in aging.
  • Role of the gut-brain axis in the development of cognitive impairment in aging.

Representative Publications

  • https://www.ncbi.nlm.nih.gov/myncbi/karienn.montgomery.1/bibliography/public/

  • Dubois, D.W., Murchison, D.A., Bang, E., Mahnke, A., Winzer-Serhan, U., Griffith, W.H., Souza, K.A.* (2023). Maintenance of optogenetic channel rhodopsin (ChR2) function in aging mice: Implications for pharmacological studies of inhibitory synaptic transmission, quantal content, and calcium homeostasis. (2023) Neuropharmachol. doi: 10.1016/j.neuropharm.2023.109651. (PMID: 37414332) *Corresponding author.

  • Souza, K. A., M. Hook and F. Sohrabji (2023) Assessing Depression and Cognitive Impairment Following Stroke and Neurotrauma: Behavioral Methods for Quantifying Impairment and Functional Recovery. Methods Mol. Biol. 2616: 263-277. (PMID: 36715941).

  • Souza, K.A*., Powell, A., Allen, G.C. and Earnest, D.J. (2022) Development of an age-dependent cognitive index: relationship between impaired learning and disturbances in circadian timekeeping. Front. Aging Neurosci. 14: 991833. doi: 10.3389/fnagi.2022.991833. (PMID: 36438000) *Corresponding author.

  • Montgomery KS, Bancroft EA, Fincher AS, Migut EA, Provasek V, Murchison D, DuBois DW (2018) Effects of ethanol and varenicline on female Sprague-Dawley rats in a third trimester model of fetal alcohol syndrome. Alcohol. 71:75-87.

  • Montgomery KS, Edwards III GE, Levites Y, Kumar A, Myers CE, Gluck MA, Setlow B, Bizon JL (2016) Deficits in hippocampal-dependent transfer generalization learning accompany synaptic dysfunction in a mouse model of amyloidosis. Hippocampus. 26: 455-471. PMID: 16806587

  • Simon, N.W., Beas, B.S., Montgomery, K.S., Haberman, R.P., Bizon, J.L., & Setlow, B. (2013). Prefrontal cortical-striatal dopamine receptor mRNA expression predicts distinct forms of impulsivity. European J. Neurosc. 37(11): 1779-1788. PMC3973541

  • Banuelos, C., Gilbert, R.J., Montgomery, K.S., Fincher, A.S., Wang, H., Frye, G.D., & Bizon, J.L. (2012). Spatial learning impairments in a human third trimester model of binge alcohol exposure in rat. Beh. Pharmacology. 23(1):54-65. PMC3303859

  • Huie, J.R., Garraway, S.M., Baumbauer, K.M., Hoy, K.C. Jr., Beas, B.S., Montgomery, K.S., Bizon, J.L., & Grau, J.W. (2012). Brain-derived neurotrophic factor (BDNF) promotes adaptive plasticity within the spinal cord and mediates the beneficial effects of controllable stimulation. Neuroscience. 200: 74-90. PMC3249495

  • Simon, N.W., Montgomery, K.S., Beas, B.S., Mitchell, M.R., LaSarge, C.L., Mendez, I.A., Bañuelos, C., Vokes, C.M., Taylor, A.B., Haberman, R.P., Bizon, J.L. & Setlow, B. (2011). Dopaminergic modulation of risky decision-making. Journal of Neuroscience. 31(48): 17460-17470. PMC3307370 

  • Montgomery, K.S., Simmons, R.K., Edwards III, G.E., Nicolle, M.M., Gluck, M.A., Myers, C.E., & Bizon, J.L. (2011). Novel age-dependent learning deficits in a mouse model of Alzheimer’s disease: implications for translational research. Neurobiol. Aging. 32(7):1273-85. PMC4334376

  • Simon, N.W., LaSarge, C.L., Montgomery, K.S., Williams, M.T., Mendez, I.A., Setlow, B., & Bizon, J.L. (2010). Good things come to those who wait: attenuated discounting of delayed reward in aging. . 31(5):853-862. PMC2866647

  • Bizon, J.L., LaSarge, C.L., Montgomery, K.S., McDermott, A.N., Setlow, B., & Griffith, W.G. (2009). Spatial reference and working memory across the lifespan of male Fischer 344 rats. Neurobiol. Aging. 30, 646-655. PMC2703480

  • Montgomery, K.S., MacKey, J., Thuett, K., Ginestra, S., Bizon, J.L., & Abbott, L.C. (2008). Chronic, low dose prenatal exposure to methylmercury (MeHg) impairs motoric and mnemonic function in adult C57/B6 mice. Beh. Brain Res. 191, 55- 61. PMID: 18436314

  • Mendez, I.A., Montgomery, K.S., LaSarge, C.L., Simon, N.W., Setlow, B., & Bizon, J.L. (2008). Long term effects of prior cocaine exposure on Morris water maze performance. Neurobiol. Learn. Mem. 89, 185 -191. PMC2258220

  • LaSarge, C.L., Montgomery, K.S., Tucker, C., Slaton, G.S., Griffith, W.H., Setlow, B., & Bizon, J. L. (2007). Deficits across multiple cognitive domains in a subset of aged Fischer 344 rats. Neurobiol. Aging. 28, 928-936. PMID: 16806587